Accuracy of High-Frequency Endoluminal Ultrasonography for Clinical Staging of Upper Tract Urothelial Carcinoma

Journal of Endourology
Jeffrey A FarnumSurena F Matin

Abstract

Staging of upper tract urothelial carcinoma (UTUC) remains a dilemma due to imaging and biopsy limitations leading to understaging. We seek to determine the accuracy of endoluminal ultrasound (ELUS) for clinical staging of UTUC. Patients evaluated for UTUC underwent retrograde pyelography, ureteroscopy, and ELUS. ELUS was performed using mechanical radial scanning at 20 MHz in B-mode with a 5F probe. Cine clips were evaluated by 2 radiologists blinded to ureteroscopic and pathology findings. Results were compared to pathology from nephroureterectomy. Inclusion criteria were patients who underwent nephroureterectomy without pretreatment or managed endoscopically for cTa-1 disease and were without recurrence for >1 year. From 2008 to 2013, 53 patients underwent ELUS without complication. Twenty-seven patients met inclusion criteria with conclusive ELUS imaging. ELUS accurately identified 16 of 21 patients with non-muscle invasive (MI) disease (18 pTa, 2 pT1, 1 CIS) and 1 of 6 patients with at least MI disease (2 pT2, 4 pT3). For MI disease, the positive predictive value (PPV), negative predictive value, and accuracy was 76.2%, 16.7%, and 63%, respectively, while for non-organ confined (OC) disease results were 0%, 81.8%, and 66.7...Continue Reading

References

Aug 1, 1997·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·J B LiuB B Goldberg
May 13, 1999·Ultrasound in Medicine & Biology·J B Liu, B B Goldberg
Mar 16, 2001·Journal of Endourology·D I LeeJ B Liu
Mar 9, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ji-Bin LiuBarry B Goldberg
Feb 11, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Sirish KondaboluSrinivas Pentyala
Nov 15, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ronan F J BrowneWilliam C Torreggiani
Aug 25, 2010·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Surena F MatinH Barton Grossman
Mar 5, 2013·Archives of Pathology & Laboratory Medicine·Vishal VashisthaDebra L Zynger
Sep 29, 2015·Journal of Endourology·Daniel BuiJoseph C Liao
Jan 12, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Masahiro JinzakiMototsugu Oya
Apr 14, 2018·The Urologic Clinics of North America·Firas G PetrosSurena F Matin

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Methods Mentioned

BETA
biopsy
surgical resection

Software Mentioned

ELUS

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