Accuracy of Magnetic Resonance Imaging/Ultrasound Fusion Targeted Biopsies to Diagnose Clinically Significant Prostate Cancer in Enlarged Compared to Smaller Prostates

The Journal of Urology
Arachk de GorskiPierre Mozer

Abstract

We assessed the accuracy of magnetic resonance imaging/transrectal ultrasound fusion biopsies to diagnose prostate cancer according to gland size. A prospective study was performed in 232 men with a first round biopsy, multiparametric magnetic resonance imaging with a lesion, a Likert score of 2 or greater and prostate specific antigen less than 10 ng/ml. All men underwent a standard 12-core protocol plus a protocol of 2 or 3 targeted cores. Significant prostate cancer was defined as at least 1 core with a Gleason score of 7 (3 + 4) or 6 with a greater than 4 mm maximal cancer core length. Mean ± SD patient age was 64 ± 6.4 years, mean prostate specific antigen was 6.65 ± 1.8 ng/ml and mean prostate volume was 40 ± 24.3 ml. The overall detection rate of clinically significant prostate cancer was 44%. The detection rate of clinically significant prostate cancer by magnetic resonance imaging-transrectal ultrasound fusion guided biopsy was 77% for prostate glands less than 30 cm(3), and 61%, 47% and 34% for glands 30 to less than 38.5, 38.5 to less than 55 and 55 to 160 cm(3), respectively (p = 0.001). Differences in prostate cancer detection rates between the standard and targeted protocols were not significant for patients with ...Continue Reading

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Citations

Jun 17, 2015·The Journal of Urology·Marc Dall'Era, Peter Carroll
Jan 24, 2019·International Urology and Nephrology·Michael WangLee Ponsky
Mar 14, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Abdullah ErdoganAbdullah Turan
Jun 18, 2016·Current Opinion in Urology·Marlon PereraNathan Lawrentschuk
Jul 20, 2019·International Urology and Nephrology·Joshua M FrostWerner T de Riese
Feb 25, 2017·Current Urology Reports·Srinivas VourgantiAndrij Wojtowycz
Jan 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Guillermo LorenzoHector Gomez
Jul 4, 2018·World Journal of Urology·Niklas WesthoffManuel Ritter
Aug 15, 2018·Prostate Cancer and Prostatic Diseases·Armando StabileCaroline M Moore
May 24, 2021·International Urology and Nephrology·Abhilash MoolupuriWerner T de Riese

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