Accuracy of marker-assisted selection with single markers and marker haplotypes in cattle

Genetical Research
B J HayesMike E Goddard

Abstract

A key question for the implementation of marker-assisted selection (MAS) using markers in linkage disequilibrium with quantitative trait loci (QTLs) is how many markers surrounding each QTL should be used to ensure the marker or marker haplotypes are in sufficient linkage disequilibrium (LD) with the QTL. In this paper we compare the accuracy of MAS using either single markers or marker haplotypes in an Angus cattle data set consisting of 9323 genome-wide single nucleotide polymorphisms (SNPs) genotyped in 379 Angus cattle. The extent of LD in the data set was such that the average marker-marker r2 was 0.2 at 200 kb. The accuracy of MAS increased as the number of markers in the haplotype surrounding the QTL increased, although only when the number of markers in the haplotype was 4 or greater did the accuracy exceed that achieved when the SNP in the highest LD with the QTL was used. A large number of phenotypic records (>1000) were required to accurately estimate the effects of the haplotypes.

References

Feb 15, 2000·Genome Research·F FarnirM Georges
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Jan 17, 2003·European Journal of Human Genetics : EJHG·Krishna YanamandraTheodore F Thurmon
Nov 3, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rachel J HawkenBrian P Dalrymple
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Jun 1, 1968·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W G Hill, A Robertson

❮ Previous
Next ❯

Citations

Mar 24, 2010·Genetics, Selection, Evolution : GSE·Han A MulderRoel F Veerkamp
May 17, 2011·Genetics, Selection, Evolution : GSE·Dorian J Garrick
Nov 14, 2012·Genetics, Selection, Evolution : GSE·Simon TeyssèdreAnne Ricard
Sep 27, 2013·BMC Genetics·Nick Vl SerãoSandra L Rodriguez-Zas
Mar 10, 2009·PloS One·James W KijasUNKNOWN International Sheep Genomics Consortium
Oct 21, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Robenzon E Lorenzana, Rex Bernardo
Dec 14, 2007·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M E Goddard, B J Hayes
Jul 17, 2013·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·J M HickeyG Gorjanc
Mar 13, 2012·Animal Genetics·J E PowellC S Haley
Mar 21, 2016·Journal of Dairy Science·Dávid JónásPascal Croiseau
Mar 24, 2016·Journal of Applied Genetics·Miguel Henrique de Almeida SantanaJosé Bento Sterman Ferraz
Jan 14, 2011·Trends in Genetics : TIG·Martha T HamblinJean-Luc Jannink
Jun 28, 2016·BMC Genetics·Enrique Sánchez-MolanoGeorgios Banos
Sep 2, 2008·Genetics·Andrés LegarraJean-Michel Elsen
Nov 20, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sabrina GiacoppoEmanuela Mazzon
Sep 29, 2019·Animals : an Open Access Journal From MDPI·Paulina BrodowskaEmilia Bagnicka
Sep 15, 2009·Journal of Animal Science·A ToosiJ C M Dekkers
Jul 5, 2017·Genetics, Selection, Evolution : GSE·Melanie HessDorian Garrick
Apr 27, 2019·Frontiers in Plant Science·Samir AlahmadLee T Hickey
Oct 6, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Adnan RiazKai P Voss-Fels
Dec 6, 2016·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·D JónásP Croiseau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.