Accuracy of Myocardial Biomarkers in the Diagnosis of Myocardial Infarction After Revascularization as Assessed by Cardiac Resonance: The Medicine, Angioplasty, Surgery Study V (MASS-V) Trial

The Annals of Thoracic Surgery
Whady A HuebRoberto Kalil Filho

Abstract

The lack of a correlation between myocardial necrosis biomarkers and electrocardiographic abnormalities after revascularization procedures has resulted in a change in the myocardial infarction (MI) definition. Patients with stable multivessel disease who underwent percutaneous or surgical revascularization were included. Electrocardiograms and concentrations of high-sensitive cardiac troponin I (cTnI) and creatine kinase (CK)-MB were assessed before and after procedures. Cardiac magnetic resonance and late gadolinium enhancement were performed before and after procedures. MI was defined as more than five times the 99th percentile upper reference limit for cTnI and 10 times for CK-MB in percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), respectively, and new late gadolinium enhancement for cardiac magnetic resonance. Of the 202 patients studied, 69 (34.1%) underwent on-pump CABG, 67 (33.2%) off-pump CABG, and 66 (32.7%) PCI. The receiver operating characteristic curve showed the accuracy of cTnI for on-pump CABG, off-pump CABG, and PCI patients was 21.7%, 28.3%, and 52.4% and for CK-MB was 72.5%, 81.2%, and 90.5%, respectively. The specificity of cTnI was 3.6%, 9.4%, and 42.1% and of CK-MB was 7...Continue Reading

References

Jun 21, 2002·The New England Journal of Medicine·Jonathan R PantingDudley J Pennell
Oct 24, 2007·European Heart Journal·Kristian ThygesenUNKNOWN Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
Feb 2, 2008·The American Journal of Cardiology·Thiago Nogueira CostaPaulo Sampaio Gutierrez
Jan 6, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·William J van GaalAdrian P Banning
Mar 1, 2012·Archives of Internal Medicine·Victor NovackDonald E Cutlip
Jun 23, 2012·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of ESC Working Group on Acute Cardiac Care

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Citations

Jul 19, 2016·Revista Española De Cardiología·Philip D Adamson, Nicholas L Mills
Dec 5, 2017·Diabetology & Metabolic Syndrome·Paulo Cury RezendeRoberto Kalil Filho
Nov 7, 2019·Database : the Journal of Biological Databases and Curation·Chaoying ZhanBairong Shen
Sep 16, 2018·The American Journal of Emergency Medicine·Tim MontriefBrit Long

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