PMID: 15252264Jul 15, 2004Paper

Accuracy of objective ambulatory accelerometry in detecting motor complications in patients with Parkinson disease

Clinical Neuropharmacology
J I HoffJ J van Hilten

Abstract

Shortcomings of existing assessment methods in Parkinson disease (PD) have led to the development of continuous ambulatory multichannel accelerometry for the assessment of the core features of PD. Although measures for hypokinesia, bradykinesia, and tremor have been validated in groups of patients with PD, it is unclear whether this method is able to detect "on" with or without dyskinesias, and "off" in individual PD patients. This study therefore addressed the accuracy of objective ambulatory accelerometry in detecting motor complications in 15 PD patients, using a self-assessment scale as gold standard. Measures for hypokinesia, bradykinesia, and tremor showed limited sensitivity (0.60-0.71) and specificity (0.66-0.76) for motor complications in individual PD patients. In the group of PD patients, comparing the "on" with the "off" state yielded statistically significant differences for tremor only. Objective dyskinesia measures correlated with time spent with dyskinesias (r = 0.89). Although validated for the measurement of hypokinesia, bradykinesia, and tremor, continuous ambulatory multichannel accelerometry currently cannot detect "on" and "off" in individual PD patients.

References

Sep 1, 1989·Archives of Neurology·R G BrownC D Marsden
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jun 6, 1997·Journal of Neuroscience Methods·R J DunnewoldJ J van Hilten
Dec 17, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·C G GoetzM S Grobman
Jul 29, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R J DunnewoldB J van Hilten
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J I HoffJ J van Hilten
Oct 5, 2001·Clinical Neuropharmacology·J I HoffB J van Hilten
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Esmaeil NikfekrDiane E Playford
Jan 9, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Noël L W KeijsersStan C A M Gielen

❮ Previous
Next ❯

Citations

Jun 3, 2010·Medical & Biological Engineering & Computing·Simone Hemm, Karin Wårdell
Nov 23, 2010·Internal Medicine·Hiroshi MitomaSatoshi Orimo
Mar 5, 2010·The International Journal of Neuroscience·Santiago Perez LloretMarcelo Merello
Jul 13, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kei UchidaGen Sobue
Jan 8, 2008·Gait & Posture·Justin J Kavanagh, Hylton B Menz
Sep 30, 2010·Archives of Physical Medicine and Rehabilitation·Marc B RietbergGert Kwakkel
Jul 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanna LopaneManuela Contin
Dec 17, 2016·Sensors·Carlos Pérez-LópezAlejandro Rodríguez-Molinero
Sep 19, 2017·Frontiers in Neurology·Alejandro Rodríguez-MolineroJoan Cabestany
Aug 30, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Noël L W KeijsersStan C A M Gielen
Mar 25, 2014·Expert Review of Medical Devices·Richard W WalkerWilliam K Gray
Sep 27, 2018·Frontiers in Computational Neuroscience·Ritesh A RamdhaniBrian H Kopell
Jan 9, 2019·Frontiers in Neurology·Jenna E ThorpKristen A Pickett
Nov 4, 2005·Age and Ageing·K M CulhaneG M Lyons
Feb 5, 2015·JMIR MHealth and UHealth·Alejandro Rodríguez-MolineroAndreu Catalá
Apr 5, 2020·Scientific Reports·Franz M J PfisterUrban M Fietzek
Aug 18, 2020·Parkinson's Disease·Trine Hørmann ThomsenKristian Winge
Apr 27, 2018·JMIR Rehabilitation and Assistive Technologies·Alejandro Rodríguez-MolineroAndreu Català
Mar 17, 2019·Medical Engineering & Physics·Murtadha D HssayeniBehnaz Ghoraani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
Noël L W KeijsersStan C A M Gielen
Journal of Neurology, Neurosurgery, and Psychiatry
J J van HiltenR A Roos
Movement Disorders : Official Journal of the Movement Disorder Society
J J van HiltenR A Roos
Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
R J DunnewoldB J van Hilten
© 2022 Meta ULC. All rights reserved