Accuracy of optical spectroscopy for the detection of cervical intraepithelial neoplasia without colposcopic tissue information; a step toward automation for low resource settings.

Journal of Biomedical Optics
José-Miguel YamalMichele Follen

Abstract

Optical spectroscopy has been proposed as an accurate and low-cost alternative for detection of cervical intraepithelial neoplasia. We previously published an algorithm using optical spectroscopy as an adjunct to colposcopy and found good accuracy (sensitivity=1.00 [95% confidence interval (CI)=0.92 to 1.00], specificity=0.71 [95% CI=0.62 to 0.79]). Those results used measurements taken by expert colposcopists as well as the colposcopy diagnosis. In this study, we trained and tested an algorithm for the detection of cervical intraepithelial neoplasia (i.e., identifying those patients who had histology reading CIN 2 or worse) that did not include the colposcopic diagnosis. Furthermore, we explored the interaction between spectroscopy and colposcopy, examining the importance of probe placement expertise. The colposcopic diagnosis-independent spectroscopy algorithm had a sensitivity of 0.98 (95% CI=0.89 to 1.00) and a specificity of 0.62 (95% CI=0.52 to 0.71). The difference in the partial area under the ROC curves between spectroscopy with and without the colposcopic diagnosis was statistically significant at the patient level (p=0.05) but not the site level (p=0.13). The results suggest that the device has high accuracy over a w...Continue Reading

References

Dec 1, 1992·The American Review of Respiratory Disease·S LamB Palcic
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P SparénH O Adami
Jan 1, 1994·Gynecologic Oncology·N RamanujamR Richards-Kortum
Feb 20, 1998·Obstetrics and Gynecology·S B CantorR Richards-Kortum
Jun 17, 2000·Photochemistry and Photobiology·C K BrooknerR Richards-Kortum
Sep 29, 2001·The Western Journal of Medicine·J SherrisC Elias
Mar 21, 2002·American Journal of Obstetrics and Gynecology·Irene GeorgakoudiMichael S Feld
Nov 8, 2002·Journal of Biomedical Optics·Yvette N MirabalRebecca Richards-Kortum
Jan 21, 2003·Emerging Infectious Diseases·Gillian D Sanders, Al V Taira
Jan 31, 2003·British Journal of Cancer·G M CliffordS Franceschi
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Rengaswamy SankaranarayananMadhavan Krishnan Nair
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Karen Basen-EngquistMichele Follen
Nov 7, 2003·Cancer·Frederick B StehmanJ Taylor Wharton
Nov 13, 2003·Applied Spectroscopy·Dennis D CoxMichele Follen
Jan 6, 2004·Obstetrics and Gynecology·John L BenedetMonique A Bertrand
Apr 22, 2004·Journal of the National Cancer Institute·Sue J GoldieEduardo Franco
May 29, 2004·American Journal of Obstetrics and Gynecology·Warner K HuhRonald D Alvarez
Dec 14, 2004·Gynecologic Oncology·Irene M OrfanoudakiEugenios E Koumantakis
Jan 5, 2005·The Lancet Oncology·Marylou Cárdenas-TuranzasScott B Cantor
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 13, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R SankaranarayananS Robles
May 25, 2005·Journal of Biomedical Optics·Sung K ChangRebecca Richards-Kortum
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Rosa LegoodRengaswamy Sankaranarayanan
Nov 18, 2005·The New England Journal of Medicine·Sue J GoldieUNKNOWN Alliance for Cervical Cancer Prevention Cost Working Group
Mar 11, 2006·Journal of Biomedical Optics·Nena M MarínRebecca Richards-Kortum
Dec 30, 2006·Journal of Lower Genital Tract Disease·Timothy DeSantisEdward Wilkinson
Jan 11, 2007·Journal of Biomedical Optics·Jonathan M LevittIrene Georgakoudi
Feb 17, 2007·Gynecologic Oncology·Judith R MourantHarriet O Smith
Feb 20, 2007·Biophysical Journal·Dizem AriflerRebecca Richards-Kortum
May 15, 2007·The New England Journal of Medicine·Jan M Agosti, Sue J Goldie
May 15, 2007·The New England Journal of Medicine·Lindsey R BadenJeffrey M Drazen
Sep 11, 2007·Gynecologic Oncology·Senthilnathan NakappanBrian M Pikkula
Jan 1, 2008·Obstetrics and Gynecology·Scott B CantorJ L Benedet
Mar 5, 2008·Journal of Biomedical Optics·Sun Young ParkRebecca Richards-Kortum

❮ Previous
Next ❯

Citations

Dec 1, 2015·Statistical Analysis and Data Mining·Jose-Miguel YamalDennis D Cox
Apr 14, 2017·Journal of Lower Genital Tract Disease·Renée M F EbischRuud L M Bekkers
Sep 9, 2016·Obstetrics and Gynecology·Marjolein HermensRuud L M Bekkers
Mar 19, 2014·Journal of Lower Genital Tract Disease·Marisa Rachel Adelman
Apr 11, 2014·Optics Express·Lu WangDennis D Cox
Apr 30, 2020·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Wenwen LiuXuemei Yan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Imaging in CNS

Here is the latest research on cell imaging and imaging modalities, including light-sheet microscopy, in the central nervous system.