Accuracy of PET quantification in [68 Ga]Ga-pentixafor PET/MR imaging of carotid plaques

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Ivo RauschJacobo Cal-González

Abstract

The aim of this study was to evaluate and correct for partial-volume-effects (PVE) on [68Ga]Ga-Pentixafor uptake in atherosclerotic plaques of the carotid arteries, and the impact of ignoring bone in MR-based attenuation correction (MR-AC). Twenty [68Ga]Ga-pentixafor PET/MR examinations including a high-resolution T2-TSE MR of the neck were included in this study. Carotid plaques located at the carotid bifurcation were delineated and the anatomical information was used for partial-volume-correction (PVC). Mean and max tissue-to-background ratios (TBR) of the [68Ga]Ga-Pentixafor uptake were compared for standard and PVC-PET images. A potential influence of ignoring bone in MR-AC was assessed in a subset of the data reconstructed after incorporating bone into MR-AC and a subsequent comparison of standardized-uptake values (SUV). In total, 34 atherosclerotic plaques were identified. Following PVC, mean and max TBR increased by 77 and 95%, respectively, when averaged across lesions. When accounting for bone in the MR-AC, SUV of plaque changed by 0.5%. Quantitative readings of [68Ga]Ga-pentixafor uptake in plaques are strongly affected by PVE, which can be reduced by PVC. Including bone information into the MR-AC yielded no clinical...Continue Reading

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Citations

Sep 12, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jakub Toczek, Laurent Riou
Oct 18, 2020·Methods : a Companion to Methods in Enzymology·Lalith Kumar Shiyam SundarThomas Beyer
Nov 5, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jakob ParkEdward J Miller

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