Accuracy of PET/MR image coregistration of cervical lesions

Nuclear Medicine Communications
Shaomin ZhangXuna Zhao

Abstract

This study aimed to evaluate the accuracy of sequential whole-body PET/MR image coregistration of cervical lesions. Twenty-five patients with cervical carcinomas underwent fluorine-18 fluorodeoxyglucose PET/MR before radiotherapy. MR-volumes of interest (VOIs), PET-VOIs, and apparent diffusion coefficient (ADC)-VOIs were outlined manually on T2-weighted MR images, PET images, and ADC maps. The difference between the lesion centers on PET and MR was determined by calculating the distance of the respective geometric center of gravity. In addition, the tumor volume contour differences were assessed using the dice similarity coefficient for PET and ADC. Results were analyzed by mean±SD and a two-sample t-test. The mean values of the center of gravity mismatch were relatively higher with lesions between PET and ADC (5.79±1.70 mm) than that between PET and MR-T2 (5.22±1.97 mm; P=0.304). Tumor location overlap difference between MR-T2 and PET images (0.64±0.13) was larger than that between ADC and PET (0.56±0.14; P=0.054). The average differences between the centers of lesions on PET and T2-weighted images were 6.25±1.91, 5.24±2.17, and 4.30±1.30 mm for MR-VOI less than 14, 14-62, and at least 62 ml. The average differences between th...Continue Reading

References

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Feb 21, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Shaomin ZhangHongzan Sun
Apr 9, 2014·Nuclear Medicine Communications·Shaomin ZhangXuna Zhao

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Citations

Jul 22, 2016·Nuclear Medicine Communications·Wouter V VogelRegina G Beets-Tan
Jul 12, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gongshun Tang

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