PMID: 15329584Aug 27, 2004Paper

Accuracy of pharmacokinetic models for predicting plasma fentanyl concentrations in lean and obese surgical patients: derivation of dosing weight ("pharmacokinetic mass")

Anesthesiology
K ShibutaniM Bairamian

Abstract

The currently available pharmacokinetic models for fentanyl were derived from normal weight patients and were not scaled to body weight. Their application to obese patients may cause overprediction of the plasma concentration of fentanyl. This study examined the influence of body weight on the predictive accuracy of two models (Anesthesiology 1990; 73:1091-102 and J Pharmacol Exp Ther 1987; 240:159-66). Further, we attempted to derive suggested dosing mass weights for fentanyl that improved predicted accuracy. Seventy patients undergoing major elective surgery with total body weight (TBW) <85 kg and body mass index <30 (Group L) and 39 patients with TBW >/=85 kg and body mass index >30 (Group O) were studied. In Group L and Group O, the mean TBW was 69 kg, and 125 kg, respectively and the mean body mass index in Group L and Group O was 24 and 44, respectively. Fentanyl infusion was used during surgery and postoperatively for analgesia. Plasma fentanyl concentrations were measured and predicted concentrations were obtained by computer simulation; 465 pairs of measured and predicted values were obtained. The influence of TBW on the performance errors of the original two models was examined with nonlinear regression analysis. Shaf...Continue Reading

References

Aug 1, 1992·Clinical Pharmacology and Therapeutics·T K HenthornM J Avram
Jan 1, 1991·Anesthesiology·S L Shafer, J R Varvel
Apr 1, 1994·Clinical Pharmacokinetics·D J Morgan, K M Bray
Sep 22, 1998·Anesthesiology·T Bouillon, S L Shafer
Sep 22, 1998·Anesthesiology·T D EganK T Muir
Dec 28, 2002·Anesthesiology·Gregory SlepchenkoMarc Raucoules-Aimé

❮ Previous
Next ❯

Citations

Dec 1, 2012·Analytical and Bioanalytical Chemistry·Adam ClouseSylvia Daunert
Jul 20, 2011·Current Treatment Options in Neurology·Roop KawNancy A Collop
Dec 17, 2009·British Journal of Anaesthesia·K CandiottiR Shankar
Aug 17, 2010·British Journal of Anaesthesia·L I CortínezP Sepulveda
Jan 6, 2006·International Anesthesiology Clinics·Paul J Samuels
Mar 28, 2012·Clinical Pharmacokinetics·Margreke J E BrillCatherijne A J Knibbe
Jan 1, 2012·Pain Management·James W Atchison, Heather K Vincent
Aug 22, 2014·Clinical Pharmacokinetics·Célia Lloret-LinaresXavier Declèves
Nov 10, 2006·Current Opinion in Anaesthesiology·Frédérique Servin
Apr 7, 2007·Current Opinion in Anaesthesiology·Aaron Joffe, Ken Wood
Jun 10, 2010·Current Opinion in Anaesthesiology·Hendrikus J m Lemmens
Jul 13, 2006·Expert Review of Neurotherapeutics·Hendrikus J M Lemmens, Jay B Brodsky
Nov 5, 2011·Journal of Clinical Anesthesia·Claire L DonohoeJohn V Reynolds
Apr 27, 2011·Best Practice & Research. Clinical Anaesthesiology·Yigal LeykinTommaso Pellis
Apr 27, 2011·Best Practice & Research. Clinical Anaesthesiology·Roman Schumann
Oct 21, 2009·Critical Care Nursing Clinics of North America·Jeanne Redlin Lowe
Oct 21, 2009·Critical Care Nursing Clinics of North America·Sonia M Astle
Aug 25, 2009·Clinics in Chest Medicine·Anthony N Passannante, Michael Tielborg
Jun 9, 2009·Burns : Journal of the International Society for Burn Injuries·Kotaro Kaneda, Tae-Hyung Han
Oct 23, 2015·Critical Care Medicine·Leena ChoiTimothy D Girard
Sep 2, 2008·Journal of Clinical Anesthesia·Brian EganLawrence C Tsen
Nov 29, 2005·Anesthesiology Clinics of North America·B Randall Brenn
Apr 9, 2014·Paediatric Anaesthesia·Constance N BurkeOlubukola Nafiu
Sep 27, 2005·Clinics in Geriatric Medicine·Jacob Dimant
Jul 12, 2005·Anesthesiology Clinics of North America·Anthony N Passannante, Peter Rock
Nov 16, 2017·British Medical Bulletin·L H LangM Maze
Oct 24, 2007·Clinical Pharmacology and Therapeutics·P Y HanB Green
Jun 8, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Peter N JohnsonJamie L Miller
Aug 28, 2019·The Annals of Pharmacotherapy·Brittany S VerkerkJan Bakker
Mar 29, 2019·Anesthesiology·Brian J Anderson, Oliver Bagshaw
Dec 6, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Chenxiao Tang, Samuel M Poloyac
Feb 27, 2017·Paediatric Drugs·Janelle D VaughnsJohannes N van den Anker
Apr 4, 2017·The Journal of Antimicrobial Chemotherapy·Robert E ArianoLavern M Vercaigne
May 26, 2018·Current Opinion in Anaesthesiology·Luis I Cortínez, Brian J Anderson
Jul 1, 2019·Drugs·Imane Belcaid, Naveen Eipe
Aug 31, 2011·Journal of Perioperative Practice·Sammy Al-Benna
Jul 9, 2017·Clinical Pharmacokinetics·Victoria C ZiesenitzJohannes N van den Anker
Oct 28, 2017·Paediatric Anaesthesia·Brian J Anderson, Nick Hg Holford
Jul 5, 2018·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Sin Yin LimPeter N Johnson
Dec 10, 2019·Journal of Clinical Pharmacology·Anil R MaharajUNKNOWN Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.