Accuracy of plasma sample methods for determination of glomerular filtration rate with 99mTc-DTPA

Annals of Nuclear Medicine
Kazuo ItohN Tamaki

Abstract

The plasma sample method following a single injection of radioactive markers has been proved to be simple and accurate for the determination of glomerular filtration rate (GFR) in clinical practice. The aim of this study was to assess clinical accuracy of single-, two- and multi-sample methods. The study was performed on 50 patients with various degrees of renal dysfunction (29 males and 21 females; aged 27 to 90 years). As a reference the true GFR (GFRt) was determined by means of the two-compartment model curve fitting 10 plasma samples following a single-injection of 99mTc-DTPA. The GFRt was compared to the GFR estimated by the Christensen and Groth's single-sample (GFRcg), two-sample (GFR2s) and multi-sample (GFRm) between 75 and 300 min after the injection. The GFRs by two- and multi-sample methods were determined with the slope and intercept algorithm and its overestimation was corrected by Brochner-Mortensen's formula. In 49 patients with GFR between 12 and 169 ml/min/1.73 m2, the standard deviation of difference (95% limits of agreement) between GFRt and GFRcg at 180 min was 6.513 ml/min/l73 m2 (-16.5 approximately 9.5 ml/min/1.73 m2), which was somewhat closer than 7.311 ml/min/1.73 m2 (-12.5 approximately 16.5 ml/min/...Continue Reading

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Citations

May 11, 2010·Journal of Feline Medicine and Surgery·Eva VandermeulenKathelijne Y Peremans
Nov 20, 2013·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Julie HephzibahRegi Oommen
Jan 9, 2008·Pediatric Transplantation·Guido Filler, Ajay P Sharma
Oct 25, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Guido FillerAbeer Yasin

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