Accuracy of preoperative tests in clinical stage I endometrial cancer: the importance of lymphadenectomy

Acta Obstetricia Et Gynecologica Scandinavica
Hanbyoul ChoJae-Hoon Kim

Abstract

To evaluate the accuracy of preoperative tests for endometrial cancer in predicting the need for lymphadenectomy. Retrospective study. Tertiary university hospital. One hundred and eighty-two patients diagnosed with clinical stage I endometrial cancer. Review of medical records of the patients preoperatively diagnosed with stage I disease at Yonsei University Health System between April 2000 and December 2007. Preoperative assessment of the tumor grade, depth of myometrial invasion and lymph node metastases were compared with final pathologic results. Survival was analyzed by Cox multivariate regression analysis. In 104 cases with preoperative tumor grade 1, the final pathology was upgraded in 19 cases (18.3%). MRI correctly differentiated among stage Ia, Ib and Ic disease in 58.2% (106/182) of patients. Of the 166 patients undergoing lymphadenectomy, 20 (12.0%) had retroperitoneal lymph node metastases. The sensitivity and specificity of MRI for detection of lymph node metastases was 45% and 80.8%, respectively. Myometrial invasion (hazard ratio = 17.14, p = 0.037) and lymph node metastases (hazard ratio = 8.94, p = 0.042) were independent prognostic factors for overall survival. Incorrect decisions might be made for a substan...Continue Reading

References

Jan 1, 1971·Acta Obstetricia Et Gynecologica Scandinavica
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Citations

Mar 8, 2012·Japanese Journal of Clinical Oncology·Hee Seung KimYong Sang Song
May 1, 2010·Expert Opinion on Medical Diagnostics·Yoshio YoshidaFumikazu Kotsuji
Mar 27, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dong Hoon SuhSoon-Beom Kang
Jan 17, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H S KimJ W Kim
Sep 16, 2011·International Journal of Cancer. Journal International Du Cancer·James NicklinUNKNOWN LACE Trial Investigators
Sep 9, 2017·Obstetrics and Gynecology·Nicole C M VisserJohanna M A Pijnenborg
Aug 31, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Chuyao ZhangWeiwei Feng
Oct 13, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hitoshi HareyamaKazuhiko Okuyama
Nov 22, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ho-Suap HahnKyung-Taek Lim
Oct 6, 2010·Journal of Gynecologic Oncology·Nan-Hee JeongSeon-Kyung Lee
Apr 19, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Thomas J CadeAndrew Dobrotwir

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