Accuracy of Rapid Point-of-Care Diagnostic Tests for Hepatitis B Surface Antigen-A Systematic Review and Meta-analysis

Journal of Clinical and Experimental Hepatology
Mehnaaz Sultan KhurooMohammad Sultan Khuroo

Abstract

Rapid point-of-care tests provide plausible diagnostic strategy for hepatitis B surface antigen (HBsAg) in low resource areas. However, their utility depends upon their overall performance. Our objective was to meta-analyze the diagnostic accuracy of rapid point-of-care tests for HBsAg. Literature search was done with the help of a metasearch engine Mettā, a query interface for retrieving articles from five leading medical databases. Studies that employed rapid point-of-care tests for detection of HBsAg and compared the results with reference test were included. Two reviewers performed quality assessment of the studies and extracted data for estimating test accuracy. Twenty-seven studies were meta-analyzed and stratified by multiple parameters. Twenty-seven studies had evaluated 49 test brands and generated 76 data points. Sensitivity of individual tests varied widely and were heterogeneous (range 43.5%-99.8%); while specificity estimates were more robust and close to 100% (range 90%-100%). Overall pooled sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratio for all tests were 97.1% (95% CI, 96.1%-97.9%), 99.9% (CI, 99.8%-100%), 118.4 (CI, 84.7-165.5), 0.032 (CI, 0.023-0.045) and 4094.7...Continue Reading

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Citations

Sep 1, 2016·Infectious Diseases in Obstetrics and Gynecology·Jodie Dionne-OdomAlan T N Tita
Oct 26, 2016·Nature Reviews. Gastroenterology & Hepatology·Jean-Pierre Allain, Ohene Opare-Sem
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Jul 18, 2020·Journal of Immunology Research·Bamory DembeleAndre Inwoley
Feb 28, 2020·Clinical Microbiology Reviews·Mindie H NguyenGeoffrey Dusheiko

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