Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders

NeuroImage
Sriyesh KrishnanJeffrey R Petrella

Abstract

Functional magnetic resonance imaging (fMRI) studies in memory impairment have detected functional alterations in medial temporal lobe (MTL) structures, notably the hippocampus. Many of these studies employ spatial normalization to place subjects in a standardized template space prior to analysis; however, little is known about the effects of local atrophy on the normalization process in structures such as the hippocampus. The purpose of this study was to compare the accuracy of spatial normalization of the hippocampus between memory-impaired patients and controls. Twenty clinically-defined mild cognitive impairment (MCI) subjects and twenty elderly controls were studied at 4T with structural and functional MRI during a memory encoding-retrieval task. Bilateral hippocampal regions-of-interest (ROIs) were manually drawn for all subjects and further divided into anterior/posterior subregions. To assess normalization accuracy to the Montreal Neurological Institute template, the percentage of each template-defined hippocampal ROI originating from true hippocampal tissue was determined for all subjects. To assess the ability of spatial normalization to equalize group differences in hippocampal volume, pre- and post-normalization hip...Continue Reading

References

Apr 29, 1998·Nature·R Epstein, N Kanwisher
Oct 27, 1998·Human Brain Mapping·J AshburnerK Friston
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Jul 17, 1999·Human Brain Mapping·J Ashburner, K J Friston
Apr 27, 2001·The Anatomical Record·A W Toga, P M Thompson
Sep 18, 2001·Human Brain Mapping·R A SperlingM S Albert
Sep 29, 2001·Science·P E DowningN Kanwisher
Nov 14, 2001·Neurobiology of Aging·B C DickersonL deToledo-Morrell
Apr 24, 2002·Neurology·R J KillianyM S Albert
May 8, 2002·Nature Reviews. Neuroscience·Matthew BrettAdrian M Owen
Dec 13, 2002·Brain : a Journal of Neurology·S M DaselaarC Jonker
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·R A SperlingM S Albert
Aug 9, 2003·Nature Reviews. Drug Discovery·Ronald C Petersen
Dec 4, 2003·NeuroImage·Khena M SwallowJeffrey M Zacks
Mar 5, 2004·Neuropsychologia·Sterling C JohnsonRichard J Caselli
Jul 6, 2004·Annals of Neurology·Bradford C DickersonReisa A Sperling
Sep 29, 2004·Medical Image Analysis·Steven RobbinsSue Whitesides
Jan 18, 2005·Journal of Neuroscience Methods·Babak A ArdekaniJay Nierenberg
Apr 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marco R HoeksmaHerman van Engeland
Apr 27, 2005·Human Brain Mapping·Marius V Peelen, Paul E Downing

❮ Previous
Next ❯

Citations

Sep 14, 2007·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Sterling C JohnsonCatherine Myers
Jun 24, 2014·Neuroinformatics·Pasquale Anthony Della RosaUNKNOWN EADC-PET Consortium
Feb 15, 2008·Expert Review of Neurotherapeutics·Steven E PrinceJeffrey R Petrella
Oct 17, 2008·Clinical Neurology and Neurosurgery·Andreas JansenStefan Knecht
Jul 2, 2008·Experimental Neurology·Roland BeisteinerChristoph Baumgartner
Oct 30, 2007·Neurobiology of Aging·Jennifer L MandziaSandra E Black
Apr 16, 2008·Journal of the American Geriatrics Society·Michele L RiesSterling C Johnson
Jul 31, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jeffrey N BrowndykeKathleen A Welsh-Bohmer
Nov 2, 2014·Cognitive Neuroscience·Sonja BlumYaakov Stern
Apr 12, 2017·Human Brain Mapping·Xueqing LiuQolamreza R Razlighi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.