Accuracy of Tissue and Sonication Fluid Sampling for the Diagnosis of Fracture-Related Infection: A Systematic Review and Critical Appraisal

Journal of Bone and Joint Infection
Jolien OnseaWillem-Jan Metsemakers

Abstract

Introduction: Intraoperatively obtained peri-implant tissue cultures remain the standard for diagnosis of fracture-related infection (FRI), although culture-negative cases may complicate treatment decisions. This paper reviews the evidence on sonication fluid and tissue sampling for the diagnosis of FRI. Methods: A comprehensive search in Pubmed, Embase and Web-of-Science was carried out on April 5, 2018, to identify diagnostic validation studies regarding sonication fluid and tissue sampling for FRI. Results: Out of 2624 studies, nine fulfilled the predefined inclusion criteria. Five studies focused on sonication fluid culture, two on PCR and two on histopathology. One additional histopathology study was found after screening of reference lists. There is limited evidence that sonication fluid culture may be a useful adjunct to conventional tissue culture, but no strong evidence that it is superior or can replace tissue culture. Regarding molecular techniques and histopathology the evidence is even less clear. Overall, studies had variable 'gold standard' criteria for comparison and poorly reported culture methods. Conclusions: Scientific evidence on sonication fluid and tissue sampling, including culture, molecular tech...Continue Reading

References

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Citations

Jan 23, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T Fintan MoriartyR Geoff Richards
Oct 30, 2019·Archives of Orthopaedic and Trauma Surgery·Willem-Jan MetsemakersUNKNOWN Fracture-Related Infection (FRI) group
Jun 23, 2020·Journal of Bone and Joint Infection·Marrit HoekstraBart C H van der Wal
Jul 28, 2019·Der Orthopäde·W PepkeM Akbar
Dec 20, 2019·Journal of Orthopaedic Trauma·Geertje A M GovaertUNKNOWN Fracture-Related Infection (FRI) Consensus Group
Mar 3, 2020·The Journal of Bone and Joint Surgery. American Volume·William T ObremskeyUNKNOWN ICM Orthopaedic Trauma Work Group*
Jul 30, 2020·International Journal of Antimicrobial Agents·Donara MargaryanAndrej Trampuz
Jan 28, 2021·Journal of Clinical Medicine·Theodoros H TosounidisPeter V Giannoudis
Nov 19, 2020·EFORT Open Reviews·Martin McNallyWillem-Jan Metsemakers
Aug 26, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M DepypereW-J Metsemakers
May 6, 2021·BMC Musculoskeletal Disorders·Cheng LiCristina Ojeda-Thies
May 15, 2021·Journal of Orthopaedic Surgery and Research·Petri BellovaHinnerk Baecker
Aug 31, 2021·Journal of Bone and Joint Infection·Daniele De MeoCiro Villani
Dec 22, 2021·Der Unfallchirurg·Jan-Dierk ClausenMohamed Omar

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Methods Mentioned

BETA
amputation
PCR
biopsy

Software Mentioned

Embase

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