Accuracy of Transperineal Targeted Prostate Biopsies, Visual Estimation and Image Fusion in Men Needing Repeat Biopsy in the PICTURE Trial

The Journal of Urology
Lucy A M SimmonsHashim Uddin Ahmed

Abstract

We evaluated the detection of clinically significant prostate cancer using magnetic resonance imaging targeted biopsies and compared visual estimation to image fusion targeting in patients requiring repeat prostate biopsies. The prospective, ethics committee approved PICTURE trial (ClinicalTrials.gov NCT01492270) enrolled 249 consecutive patients from January 11, 2012 to January 29, 2014. Men underwent multiparametric magnetic resonance imaging and were blinded to the results. All underwent transperineal template prostate mapping biopsies. In 200 men with a lesion this was preceded by visual estimation and image fusion targeted biopsies. As the primary study end point clinically significant prostate cancer was defined as Gleason 4 + 3 or greater and/or any grade of cancer with a length of 6 mm or greater. Other definitions of clinically significant prostate cancer were also evaluated. Mean ± SD patient age was 62.6 ± 7 years, median prostate specific antigen was 7.17 ng/ml (IQR 5.25-10.09), mean primary lesion size was 0.37 ± 1.52 cc with a mean of 4.3 ± 2.3 targeted cores per lesion on visual estimation and image fusion combined, and a mean of 48.7 ± 12.3 transperineal template prostate mapping biopsy cores. Transperineal temp...Continue Reading

Associated Clinical Trials

Dec 14, 2011·Professor Mark Emberton

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Citations

Mar 2, 2019·BJU International·Monique J RoobolArnout R Alberts
Apr 26, 2019·The Cochrane Database of Systematic Reviews·Frank-Jan H DrostIvo G Schoots
Mar 1, 2020·Nature Reviews. Clinical Oncology·Derek J Lomas, Hashim U Ahmed
Oct 24, 2019·Current Opinion in Urology·Joseph M NorrisVeeru Kasivisvanathan
Apr 8, 2020·World Journal of Urology·M NoureldinH U Ahmed
Mar 23, 2021·Current Urology Reports·Masatomo KanekoAndre Luis Abreu
Aug 7, 2021·The British Journal of Radiology·Simona IppolitiTristan Barrett
Sep 8, 2021·BJU International·Shaan A SetiaSrinivas Vourganti

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