Accuracy of whole-body 18F-FDP-PET for restaging malignant lymphoma

Acta medica Austriaca
P MikoschP Lind

Abstract

The aim of this retrospective study was to evaluate the accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET) images, which were interpreted under daily routine conditions, in patients with Hodgkin's disease (HD) or non-Hodgkin lymphoma (NHL) for restaging after chemotherapy and/or radiotherapy. For this purpose, 18F-FDG-PET results were compared with morphological imaging methods and the patients' clinical background. 121 PET images of 93 lymphoma patients (44 HD, 49 NHL) were investigated after chemotherapy/radiotherapy. For PET imaging, 160-200 MBq 18F-FDG was administered intravenously, followed by an infusion of 20 mg Furosemid in 250 mL saline. Whole-body 18F-FDG-PET images were obtained using a partial-ring PET scanner without attenuation correction. The morphological imaging consisted in computed tomography and ultrasound (CT/US) in all patients, additional MRI in some patients, and iliac crest biopsy in cases of suspicious bone marrow involvement. The standard of reference was composed of biopsy data, clinical status at the time of investigation, and follow-up of at least 12 months. The PET images were evaluated for their sensitivity, specificity and accuracy based on written reports, wh...Continue Reading

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Citations

Oct 10, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H S HanI S Lossos
Oct 6, 2007·Blood·Thomas C KweeRutger A J Nievelstein
Oct 4, 2014·Journal of the American College of Radiology : JACR·Chul S HaLouis S Constine
Jun 15, 2010·Current Problems in Cancer·Andrea NgMichael J Yunes
Jul 16, 2008·Radiologic Clinics of North America·Heiko Schöder, Craig Moskowitz
Aug 16, 2005·Seminars in Nuclear Medicine·Guy JerusalemGeorges Fillet
Dec 14, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Teruhiko TerasawaHirokazu Nagai

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