Accurate and robust whole-head segmentation from magnetic resonance images for individualized head modeling.

NeuroImage
Oula PuontiAxel Thielscher

Abstract

Transcranial brain stimulation (TBS) has been established as a method for modulating and mapping the function of the human brain, and as a potential treatment tool in several brain disorders. Typically, the stimulation is applied using a one-size-fits-all approach with predetermined locations for the electrodes, in electric stimulation (TES), or the coil, in magnetic stimulation (TMS), which disregards anatomical variability between individuals. However, the induced electric field distribution in the head largely depends on anatomical features implying the need for individually tailored stimulation protocols for focal dosing. This requires detailed models of the individual head anatomy, combined with electric field simulations, to find an optimal stimulation protocol for a given cortical target. Considering the anatomical and functional complexity of different brain disorders and pathologies, it is crucial to account for the anatomical variability in order to translate TBS from a research tool into a viable option for treatment. In this article we present a new method, called CHARM, for automated segmentation of fifteen different head tissues from magnetic resonance (MR) scans. The new method compares favorably to two freely av...Continue Reading

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Citations

Feb 16, 2021·NeuroImage. Clinical·Egill Axfjord FridgeirssonGuido A van Wingen
Nov 13, 2020·Journal of Neural Engineering·Guilherme B SaturninoAxel Thielscher
Aug 3, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cihan GöksuAxel Thielscher

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Software Mentioned

CHARM
SimNIBS
ROASTv2
Mesh
iSEG
MATLAB
mDixon
HEADRECO
FreeSurfer
ROAST

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