Accurate assessment of alpha-gal syndrome using cetuximab and bovine thyroglobulin-specific IgE

Molecular Nutrition & Food Research
Da Woon SimJung-Won Park

Abstract

IgE against galactose-α-1,3-galactose (α-Gal) causes alpha-gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against cetuximab as compared to BTG for diagnosing alpha-gal syndrome. Twelve patients with alpha-gal syndrome, 11 patients with immediate beef or pork allergy, 18 asymptomatic individuals with meat sensitization, and 10 non-atopic subjects were enrolled. We checked the levels of sIgE against BTG and cetuximab using the streptavidin CAP assay. Additionally, IgE reactivity to BTG and cetuximab was assessed by immunoblotting. All alpha-gal syndrome patients had a high concentration of sIgE against BTG, and cetuximab. In contrast to alpha-gal syndrome, patients with immediate allergic reactions to meat consumption and those with asymptomatic sensitization had significantly lower concentration of BTG and cetuximab sIgE, and a high prevalence of sIgE against bovine or porcine serum albumin. Although the concentration of sIgE against alpha-gal was lower in individuals with asymptomatic sensitization, IgE immunoblotting showed the presence of sIgE against α-Gal in this group. Differentiation of alpha-gal syndrome from patients with immediate alle...Continue Reading

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Citations

Feb 8, 2018·Allergy, Asthma & Immunology Research·Hye Jung ParkJung Won Park
Jun 17, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Krzyszof RutkowskiAnna Moniuszko-Malinowska
Mar 27, 2019·Allergy, Asthma & Immunology Research·Sung Ryeol KimJung Won Park
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