Accurate determination of hexabromocyclododecane diastereomers in extruded high-impact polystyrene: Development of an analytical method as a candidate reference method

Chemosphere
Song-Yee BaekSeonghee Ahn

Abstract

Herein, an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) method was developed as a candidate reference method for the accurate quantitation of hexabromocyclododecane (HBCDD) diastereomers in plastics. The repeatability, reproducibility, and uncertainty results showed that developed ID-LC/MS/MS method is reliable and reproducible. As homogeneous samples, HBCDD-containing extruded high-impact polystyrene (HIPS) pellets were fabricated via an extrusion process. Notably, we detected α-, β-, γ-, δ-, ε-, η-, and θ-HBCDDs in the extruded HIPS pellets, and then determined their exact mass fractions using the ID-LC-MS/MS method. The relative contents (average ± standard deviation) of HBCDD diastereomers in HIPS obtained using the phenyl-hexyl column were 67.08 ± 0.41% (α-HBCDD), 19.73 ± 0.37% (β-HBCDD), 11.59 ± 0.16% (γ-HBCDD), and 1.6 ± 0.07% (sum of δ-, ε-, η-, and θ-HBCDDs). These values differed significantly from the ones determined for the technical HBCDD mixtures (10.42% α-HBCDD, 5.30% β-HBCDD, 82.13% γ-HBCDD, 2.15% minor HBCDDs) used to fabricate the HIPS pellets and thus demonstrating the HBCDD isomerization during the extrusion. The proportion of minor HBCDDs was smaller than the uncertainty of ...Continue Reading

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