Accurate estimation of microscopic diffusion anisotropy and its time dependence in the mouse brain

NeuroImage
Andrada IanuşNoam Shemesh

Abstract

Microscopic diffusion anisotropy (μA) has been recently gaining increasing attention for its ability to decouple the average compartment anisotropy from orientation dispersion. Advanced diffusion MRI sequences, such as double diffusion encoding (DDE) and double oscillating diffusion encoding (DODE) have been used for mapping μA, usually using measurements from a single b shell. However, the accuracy of μA estimation vis-à-vis different b-values was not assessed. Moreover, the time-dependence of this metric, which could offer additional insights into tissue microstructure, has not been studied so far. Here, we investigate both these concepts using theory, simulation, and experiments performed at 16.4T in the mouse brain, ex-vivo. In the first part, simulations and experimental results show that the conventional estimation of microscopic anisotropy from the difference of D(O)DE sequences with parallel and orthogonal gradient directions yields values that highly depend on the choice of b-value. To mitigate this undesirable bias, we propose a multi-shell approach that harnesses a polynomial fit of the signal difference up to third order terms in b-value. In simulations, this approach yields more accurate μA metrics, which are simil...Continue Reading

Citations

Jan 17, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rafael Neto HenriquesNoam Shemesh
Sep 14, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Markus NilssonPia C Sundgren
Nov 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Aidin ArbabiCorey A Baron
Oct 28, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Leevi KerkeläNoam Shemesh
Nov 27, 2020·Journal of Neuroscience Methods·Filip SzczepankiewiczMarkus Nilsson
Nov 5, 2020·Journal of Neuroscience Methods·Rafael N HenriquesAndrada Ianuş
Jul 31, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rafael Neto HenriquesNoam Shemesh
Sep 14, 2021·NMR in Biomedicine·Tabinda SarwarAndrew Zalesky
Apr 14, 2020·NeuroImage·Michiel CottaarSaad Jbabdi

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