Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra

Magnetic Resonance in Chemistry : MRC
Keyvan GhasemiH Saligheh Rad

Abstract

Hydrogen magnetic resonance spectroscopy ((1) H-MRS) is a non-invasive technique which provides a 'frequency-signal intensity' spectrum of biochemical compounds of tissues in the body. Although this method is currently used in human brain studies, accurate classification of in-vivo (1) H-MRS is a challenging task in the diagnosis of brain tumors. Problems such as overlapping metabolite peaks, incomplete information on background component and low signal-to-noise ratio disturb classification results of this spectroscopic method. This study presents an alternative approach to the soft independent modeling of class analogy (SIMCA) technique, using non-negative matrix factorization (NMF) for dimensionality reduction. In the adopted strategy, the performance of SIMCA was improved by application of a robust algorithm for classification in the presence of noisy measurements. Total of 219 spectra from two databases were taken by water-suppressed short echo-time (1) H-MRS, acquired from different subjects with different stages of glial brain tumors (Grade II (26 cases), grade III (24 cases), grade IV (41 cases), as well as 25 healthy cases). The SIMCA was performed using two approaches: (i) principal component analysis (PCA) and (ii) no...Continue Reading

References

Jun 22, 2000·NMR in Biomedicine·V GovindarajuA A Maudsley
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A Rosemary TateCarles Arús
Jan 9, 2004·Analytical Chemistry·Arjan W SimonettiLutgarde M C Buydens
Apr 4, 2006·Analytical Chemistry·Andrew CraigJohn C Lindon
Aug 10, 2006·Journal of Magnetic Resonance Imaging : JMRI·Carolyn MountfordPeter Russell
Aug 3, 2007·Journal of Cancer Research and Clinical Oncology·Mohammadreza KhanmohammadiAmir Bagheri Garmarudi
May 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alan J WrightFranklyn A Howe
Nov 21, 2009·IEEE Transactions on Pattern Analysis and Machine Intelligence·Chris DingMichael I Jordan
Apr 15, 2010·Chemical Reviews·Carolyn E MountfordBrian Ross
Apr 27, 2010·Analytica Chimica Acta·Jan LutsJohan A K Suykens
Jan 19, 2011·International Journal of Neural Systems·Raúl Cruz-Barbosa, Alfredo Vellido
Jul 29, 2011·NMR in Biomedicine·F RaschkeF A Howe
May 18, 2012·Metabolomics : Official Journal of the Metabolomic Society·Stefanie M KohlWolfram Gronwald
Oct 6, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Javier VicenteAndrew C Peet
Dec 15, 2012·Clinical Neurology and Neurosurgery·Martin BulikMarek Mechl
Dec 15, 2012·NMR in Biomedicine·Elies Fuster-GarciaJuan M García-Gómez
Jan 29, 2013·PloS One·Richard J EllisMark E Viney
May 21, 2013·Analytica Chimica Acta·Gemma M KirwanMichael J Adams

❮ Previous
Next ❯

Citations

Dec 12, 2019·NMR in Biomedicine·Valeria RighiMarina Cocchi
Dec 4, 2019·NMR in Biomedicine·Yanisleydis Hernández-VillegasMargarida Julià-Sapé

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.