Accurate identification of HER2-positive patients is essential for superior outcomes with trastuzumab therapy

Oncology Nursing Forum
Nathalie Chorn

Abstract

To review the clinical significance, methods of testing, and outcomes of trastuzumab (Herceptin) treatment for HER2 gene amplification and HER2 protein overexpression in breast cancer. Published articles and abstracts, online resources, a clinical handbook, and product information. HER2 gene amplification or HER2 protein overexpression can be found in 20%-25% of breast cancers and is important pathogenic and prognostic information. HER2 also predicts patient response to trastuzumab. Patients with HER2-positive metastatic breast cancer benefit from trastuzumab whether selected by immunohistochemistry, which measures the HER2 protein, or fluorescence in situ hybridization (FISH), which measures the HER2 oncogene. However, patients who are identified accurately as HER2 gene-amplified by FISH derive the greatest benefit. Accurate testing is crucial for appropriate identification of patients for trastuzumab therapy. FISH is the most reproducible and accurate method. Education regarding HER2 testing and trastuzumab helps patients to make informed decisions and facilitates active participation in their care as well as enhances dialogue with physicians.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·O P KallioniemiJ W Gray
Mar 15, 1992·Cancer·J W Gray, D Pinkel
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T G CookeW D George
Mar 1, 1991·British Journal of Cancer·J WinstanleyP S Rudland
Aug 31, 1991·Lancet·C W TaylorA Goldhirsch
Jan 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PaikC R King
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CarlomagnoS De Placido
Aug 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M F PressK J Flom
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S SjögrenJ Bergh
Mar 5, 1999·Breast Cancer Research and Treatment·R M Elledge, D C Allred
Aug 24, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R L RidolfiJ M Arber
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D A BerryL Norton
Oct 31, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G PaulettiD J Slamon
Feb 15, 2001·Cancer Control : Journal of the Moffitt Cancer Center·J Horton
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R C BastUNKNOWN American Society of Clinical Oncology Tumor Markers Expert Panel
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H YamauchiD F Hayes
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R R TubbsT M Grogan
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H J BursteinE P Winer
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SchallerH Bühler
Oct 23, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·H YamauchiD F Hayes
Dec 18, 2001·The Journal of Pathology·J M BartlettT G Cooke
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Mar 22, 2002·Nature·Yotaro IzumiRakesh K Jain
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francisco J EstevaGabriel N Hortobagyi
Jun 6, 2002·Journal of the National Cancer Institute·Soonmyung PaikNorman Wolmark
Jun 6, 2002·Journal of the National Cancer Institute·Patrick C RocheEdith A Perez
Jun 29, 2002·Archives of Pathology & Laboratory Medicine·UNKNOWN Cell Markers And Cytogenetics Committees College Of American Pathologists
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael F PressLeslie Bernstein
Jul 10, 2003·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·E Thomas, G Berner
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael F PressDennis J Slamon

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Citations

Jun 10, 2010·Clinical Journal of Oncology Nursing·Frances M PalmieriEdith A Perez
Aug 29, 2014·Platelets·Walter J Janse van RensburgJan P Roodt
May 2, 2007·Advances in Anatomic Pathology·Rohit Bhargava, David J Dabbs

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