Accurate identification of myocardial viability after myocardial infarction with novel manganese chelate-based MR imaging

NMR in Biomedicine
Ling-Yi WenYing-Kun Guo

Abstract

We developed a novel manganese (Mn2+ ) chelate for magnetic resonance imaging (MRI) assessment of myocardial viability in acute and chronic myocardial infarct (MI) models, and compared it with Gadolinium-based delay enhancement MRI (Gd3+ -DEMRI) and histology. MI was induced in 14 rabbits by permanent occlusion of the left circumflex coronary artery. Gd3+ -DEMRI and Mn2+ chelate-based delayed enhancement MRI (Mn2+ chelate-DEMRI) were performed at 7 days (acute MI, n = 8) or 8 weeks (chronic MI, n = 6) after surgery with sequential injection of 0.15 mmol/kg Gd3+ and Mn2+ chelate. The biodistribution of Mn2+ in tissues and blood was measured at 1.5 and 24 h. Blood pressure, heart rate (HR), left ventricular (LV) function, and infarct fraction (IF) were analyzed, and IF was compared with the histology. The Mn2+ chelate group maintained a stable hemodynamic status during experiment. For acute and chronic MI, all rabbits survived without significant differences in HR or LV function before and after injection of Mn2+ chelate or Gd3+ (p > 0.05). Mn2+ chelate mainly accumulated in the kidney, liver, spleen, and heart at 1.5 h, with low tissue uptake and urine residue at 24 h after injection. In the acute MI group, there was no signific...Continue Reading

References

Jul 1, 1983·AJR. American Journal of Roentgenology·G L Wolf, L Baum
Oct 1, 1983·Seminars in Nuclear Medicine·M H Mendonça-DiasP C Lauterbur
Jan 1, 1997·Acta Physiologica Scandinavica·H BrurokP Jynge
Mar 17, 1999·Journal of Magnetic Resonance Imaging : JMRI·R WyttenbachC B Higgins
Nov 24, 2004·Journal of Magnetic Resonance Imaging : JMRI·Arne SkjoldHenrik B W Larsson
Aug 7, 2007·The Journal of Veterinary Medical Science·Miori KishimotoYoh-Ichi Miyake
Aug 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Arne SkjoldPer Jynge
Feb 23, 2010·NMR in Biomedicine·Bénédicte M A DelattreJean-Paul Vallée
Dec 18, 2010·European Heart Journal·Frank A FlachskampfWerner G Daniel
Oct 11, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Franciane B FiórioRegiane Albertini de Carvalho
Oct 31, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Hongying SuHua Ai
Apr 6, 2013·Journal of Magnetic Resonance Imaging : JMRI·Kristine SkårdalMarte Thuen
May 3, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Jeanette Schulz-MengerEike Nagel
Nov 8, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Eszter BorosPeter Caravan
Nov 21, 2015·Journal of the American Chemical Society·Eric M GalePeter Caravan
Apr 9, 2016·Journal of the American College of Cardiology·Gregg W StoneOri Ben-Yehuda
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 27, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajiv SaranVahakn Shahinian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
Xiaoguang ZhuMing Zhao
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Boban Thomas, Nuno Jalles Tavares
© 2021 Meta ULC. All rights reserved