Accurate Lipophilicity (log P) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry

Angewandte Chemie
David O'Hagan, Robert J Young

Abstract

Polar exploration: Recently, Linclau and co-workers disclosed a straightforward (19)F-NMR method for determining the log P values of fluorocarbons. The method is particularly useful for most polar compounds and provides a quantitative way to rationalize the more subtle stereoelectronic consequences of fluorine introduction.

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Citations

May 13, 2017·Inorganic Chemistry·Raja MitraKlaus-Richard Pörschke
Nov 11, 2019·Magnetic Resonance in Chemistry : MRC·Renan V Viesser, Cláudio F Tormena
Dec 14, 2017·Beilstein Journal of Organic Chemistry·Vladimir Kubyshkin, Nediljko Budisa
Jul 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingzhu ZhangYupeng Tian
Oct 24, 2020·Beilstein Journal of Organic Chemistry·Daniela Rodrigues SilvaMatheus P Freitas
Jul 17, 2021·Organic & Biomolecular Chemistry·Francisco A Martins, Matheus P Freitas
May 14, 2020·Ecotoxicology and Environmental Safety·Francisco A MartinsMatheus P Freitas

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