PMID: 9447442Jan 1, 1997Paper

Accurate prediction of histologically confirmed Alzheimer's disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and APO E4 medial temporal lobe dementias. The Oxford Project to Investigate Memory and Aging

International Psychogeriatrics
K A JobstB J Shepstone

Abstract

In a prospective study of more than 200 cases of dementia and 119 controls, annual technetium-99m-hexamethyl-propylene amineoxime (99mTc-HMPAO) single-photon emission computed tomography (SPECT) and annual medial temporal lobe (MTL) oriented X-ray computed tomography (CT) have been used to evaluate the diagnostic potential of functional and structural neuroimaging in the differential diagnosis of dementia. Some subjects have had up to 7 annual evaluations. So far, of 151 who have died, 143 (95%) have come to necropsy. Histology is known for 118, of whom 80 had Alzheimer's disease (AD), 24 had other "non-AD" dementias, and 14 controls with no cognitive deficit in life also had no significant central nervous system pathology. To compare the findings in the dementias with the profile of structural and functional imaging in the cognitively normal elderly, scan data from 105 living, elderly controls without cognitive deficit have also been included in the analysis. All clinical diagnoses were according to National Institute of Neurological and Communicable Disease and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; DSM-III-R) cr...Continue Reading

Citations

Jun 27, 2000·Neurobiology of Aging·K A Johnson, M S Albert
Mar 22, 2005·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Dhiren Singh
Feb 19, 2011·Alzheimer's Research & Therapy·Jonathan H WilliamsA David Smith
Feb 4, 2003·Radiology·Jeffrey R PetrellaP Murali Doraiswamy
Oct 16, 2015·Journal of Neuropathology and Experimental Neurology·Jesper O E CarlsonLotte Gerritsen
Oct 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Tiffany Chow
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Mar 7, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fumihito YoshiiWakoh Takahashi
Jul 20, 2010·Journal of Mental Health·Dror Ben-ZeevPatrick W Corrigan
Jul 8, 2000·International Journal of Geriatric Psychiatry·M Marshall

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