Abstract
Background: Intracranial hemangiopericytoma (IHPC) and meningioma are both meningeal neoplasms, but they have extremely different malignancy and outcomes. Because of their similar radiological characteristics, they are difficult to distinguish prior to surgery, leading to a high rate of misdiagnosis. Methods: We enrolled 292 patients (IHPC, 155; meningiomas, 137) with complete clinic-radiological and histopathological data, from a 10-year database established at Tiantan hospital. Radiomics analysis of tumor and peritumoral edema was performed on multisequence magnetic resonance images, and a fusion radiomics signature was generated using a machine-learning strategy. By combining clinic-radiological data with the fusion radiomics signature, we developed an integrated diagnostic approach that we named the IHPC and Meningioma Diagnostic Tool (HMDT). Results: The HMDT displayed remarkable diagnostic ability, with areas under the curve (AUCs) of 0.985 and 0.917 in the training and validation cohorts, respectively. The calibration curve showed excellent agreement between the diagnosis predicted by HMDT and the histological outcome, with p-values of 0.801 and 0.622 for the training and the validation cohorts, respectively. Cross-valid...Continue Reading
References
Dec 1, 1985·Ophthalmology·M BoniukR L Font
Jan 9, 2001·Journal of Neurosurgery·I BarbaC Arús
Sep 6, 2001·Acta neurochirurgica·J F AlénJ R Ricoy
Jan 7, 2004·Journal of Neurosurgery·Frederic P CollignonDavid G Piepgras
Mar 26, 2004·Cancer·Serdar SoyuerMoshe H Maor
Nov 30, 2006·European Radiology·N A SibtainS E J Connor
Jul 1, 1942·Annals of Surgery·A P Stout, M R Murray
Aug 3, 2010·Journal of Neurosurgery·Marco SchiaritiNeil Kitchen
Aug 13, 2011·Cancer·Martin J RutkowskiAndrew T Parsa
Dec 14, 2011·AJNR. American Journal of Neuroradiology·Q ChenJ-P Dai
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Jun 5, 2012·European Journal of Radiology·Jun-lin ZhouMing Zhang
Mar 7, 2013·Journal of Magnetic Resonance Imaging : JMRI·Gang LiuYu-Lin Wang
Jan 15, 2014·Journal of Neuroradiology. Journal De Neuroradiologie·N MamaK Tlili-Graiess
Feb 15, 2014·Journal of Neuroradiology. Journal De Neuroradiologie·Li LiuWei-jun Peng
Oct 30, 2015·Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
May 4, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yan-Qi HuangZai-Yi Liu
Oct 19, 2016·Radiology·Hui LiMaryellen L Giger
May 10, 2016·Acta Neuropathologica·David N LouisDavid W Ellison
May 4, 2017·Clinical Neuroradiology·Nader ZakhariThanh B Nguyen
Sep 25, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhenyu LiuYing-Shi Sun
Oct 5, 2017·Nature Reviews. Clinical Oncology·Philippe LambinSean Walsh
Nov 23, 2017·Radiology·Huaiqiang SunQiyong Gong
Feb 14, 2018·Neuro-oncology·Daesung KangHo Sung Kim
Sep 22, 2018·World Neurosurgery·Tokunori KanazawaHikaru Sasaki
Feb 20, 2019·European Journal of Radiology·Wenle HeYuankui Wu
Citations
Mar 3, 2021·Neuroradiology·Lorenzo UggaArturo Brunetti
Mar 12, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Akira KunimatsuOsamu Abe
Mar 29, 2021·European Journal of Radiology·So Yeon WonSeung-Koo Lee
Apr 4, 2021·Journal of Clinical Medicine·Darius KalasauskasNaureen Keric
Jul 27, 2021·Frontiers in Oncology·Zhen ZhaoHongyang Zhao
Nov 9, 2021·Frontiers in Oncology·Ning LiXiaojun Xu