Oct 27, 2018

Accurate risk estimation of β-amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Sebastian PalmqvistOskar Hansson

Abstract

The aim was to create readily available algorithms that estimate the individual risk of β-amyloid (Aβ) positivity. The algorithms were tested in BioFINDER (n = 391, subjective cognitive decline or mild cognitive impairment) and validated in Alzheimer's Disease Neuroimaging Initiative (n = 661, subjective cognitive decline or mild cognitive impairment). The examined predictors of Aβ status were demographics; cognitive tests; white matter lesions; apolipoprotein E (APOE); and plasma Aβ42/Aβ40, tau, and neurofilament light. Aβ status was accurately estimated in BioFINDER using age, 10-word delayed recall or Mini-Mental State Examination, and APOE (area under the receiver operating characteristics curve = 0.81 [0.77-0.85] to 0.83 [0.79-0.87]). When validated, the models performed almost identical in Alzheimer's Disease Neuroimaging Initiative (area under the receiver operating characteristics curve = 0.80-0.82) and within different age, subjective cognitive decline, and mild cognitive impairment populations. Plasma Aβ42/Aβ40 improved the models slightly. The algorithms are implemented on http://amyloidrisk.com where the individual probability of being Aβ positive can be calculated. This is useful in the workup of prodromal Alzheime...Continue Reading

  • References44
  • Citations4

References

  • References44
  • Citations4

Mentioned in this Paper

Mini-mental State Examination
Neurofilament
APP protein, human
Cross Validation
Alzheimer's Disease
Amyloid Deposition
APOE
Amyloid
APOE Gene Product
Cognition Disorders

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