ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Hatem M AbuohashishSalim S Al-Rejaie

Abstract

The local role of the renin angiotensin system (RAS) was documented recently beside its conventional systemic functions. Studies showed that the effector angiotensin II (AngII) alters bone health, while inhibition of the angiotensin converting enzyme (ACE-1) preserved these effects. The newly identified Ang1-7 exerts numerous beneficial effects opposing the AngII. Thus, the current study examines the role of Ang1-7 in mediating the osteo-preservative effects of ACEI (captopril) through the G-protein coupled Mas receptor using an ovariectomized (OVX) rat model of osteoporosis. 8 weeks after the surgical procedures, captopril was administered orally (40mgkg-1 d-1), while the specific Mas receptor blocker (A-779) was delivered at infusion rate of 400ngkg-1min-1 for 6 weeks. Bone metabolic markers were measured in serum and urine. Minerals concentrations were quantified in serum, urine and femoral bones by inductive coupled plasma mass spectroscopy (ICP-MS). Trabecular and cortical morphometry was analyzed in the right distal femurs using micro-CT. Finally, the expressions of RAS peptides, enzymes and receptors along with the receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) were determined femurs heads. OVX anim...Continue Reading

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Citations

Oct 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·MinLong ZhangFaguang Jin
Jun 12, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Michele M Ciulla
Sep 3, 2019·Biological & Pharmaceutical Bulletin·Xiaoying YuFeifei Zhu
Aug 1, 2020·Journal of Bone and Mineral Metabolism·Caiyan MoBaoyu Zhang
Mar 23, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hisashi KaiAtsushi Katoh
Aug 22, 2021·Molecular Biology Reports·Fernanda Rocha Chaves MoreiraAna Cristina Simões E Silva
Aug 28, 2021·Biomedicines·Francesco NappiSanjeet Singh Avtaar Singh
Dec 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rinaldo Florencio-SilvaPaulo S Cerri

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