Ace gene dosage influences the development of renovascular hypertension

Clinical and Experimental Pharmacology & Physiology
Alexandre CeroniMaria C Irigoyen

Abstract

1. Clinical and experimental evidence highlights the importance of the renin-angiotensin system in renovascular hypertension. Furthermore, genetic factors affecting angiotensin-converting enzyme (ACE) could influence the development of renovascular hypertension. 2. To test the effect of small gene perturbations on the development of renovascular hypertension, mice harbouring two or three copies of the Ace gene were submitted to 4 weeks of two-kidney, one-clip (2K1C) hypertension. Blood pressure (BP), cardiac hypertrophy, baroreflex sensitivity and blood pressure and heart rate variability were assessed and compared between the different groups. 3. The increase in BP induced by 2K1C was higher in mice with three copies of the Ace gene compared with mice with only two copies (46 vs 23 mmHg, respectively). Moreover, there was a 3.8-fold increase in the slope of the left ventricle mass/BP relationship in mice with three copies of the Ace gene. Micewith three copies of the Ace gene exhibited greater increases in cardiac and serum ACE activity than mice with only two copies of the gene. Both baroreflex bradycardia and tachycardia were significantly depressed in mice with three copies of the Ace gene after induction of 2K1C hypertensi...Continue Reading

References

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Citations

Feb 22, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Carla S CeronJose E Tanus-Santos
Apr 9, 2015·Pharmaceutical Biology·Yusof KamisahHj Mohd Saad Qodriyah
Aug 1, 2016·Kidney International·Bruno E BalboLuiz F Onuchic
Apr 3, 2013·American Journal of Hypertension·Kanchan BhatiaJennifer C Sullivan

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