ACE gene polymorphism and losartan treatment in type 2 diabetic patients with nephropathy

Journal of the American Society of Nephrology : JASN
Hans-Henrik ParvingBarry M Brenner

Abstract

Losartan treatment reduced renal outcomes in proteinuric patients with type 2 diabetes in the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) study. It is unknown whether an insertion (I)/deletion (D) polymorphism in the angiotensin I-converting enzyme (ACE) gene predicts renal outcomes and death and influences the effect of losartan in these patients. Pharmacogenetic analyses were performed comparing losartan with placebo administered with conventional blood pressure-lowering therapy in 1435 (95%) of the 1513 RENAAL study patients. The primary endpoint was the composite of doubling of baseline serum creatinine concentration, end-stage renal disease (ESRD) or death. Cox regression models were stratified on baseline proteinuria and included treatment, geographic region, ACE/ID genotype, and treatment x genotype interaction. Within the placebo group, subjects with the ID or DD genotype were more likely than those with the II genotype to reach the composite endpoint (by 17.5% and 38.1%, respectively, P = 0.029) or its individual components. Within the losartan group, genotype did not correlate with reaching the composite endpoint. Compared with placebo, however, losartan reduced the risk of rea...Continue Reading

References

Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P RuggenentiG Remuzzi
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Frank G H van der KleijGerjan Navis
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·B M BrennerUNKNOWN RENAAL Study Investigators
Aug 13, 2002·European Journal of Human Genetics : EJHG·Florent SoubrierMartin Farrall
Feb 7, 2003·The New England Journal of Medicine·Richard Weinshilboum
Feb 7, 2003·The New England Journal of Medicine·William E Evans, Howard L McLeod
Mar 13, 2003·Kidney International·William F KeaneUNKNOWN RENAAL Study Investigators
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Peter JacobsenHans-Henrik Parving
Oct 2, 2004·Kidney International·Kasper RossingHans-Henrik Parving
Aug 10, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Peter Karl Jacobsen
Oct 26, 2005·Current Controlled Trials in Cardiovascular Medicine·Madlaina ScharplatzLucas M Bachmann

❮ Previous
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Citations

Aug 12, 2009·European Journal of Clinical Pharmacology·Melanie S JoyJoyce A Goldstein
May 22, 2010·Cardiovascular Drugs and Therapy·Christian W Mende
Jul 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maarten J Postma, Dick de Zeeuw
Jul 31, 2008·BMC Musculoskeletal Disorders·Chenchen WangTimothy McAlindon
Jun 11, 2010·Indian Journal of Nephrology·V V S NareshV Siva Kumar
Oct 1, 2012·Journal of Nephropathology·Zohreh Rahimi
Jun 6, 2008·The New England Journal of Medicine·Hans-Henrik ParvingUNKNOWN AVOID Study Investigators
Jan 28, 2010·Expert Opinion on Drug Metabolism & Toxicology·Kim TaverneOlaf Klungel
Feb 10, 2012·Kidney International·Hirofumi TomitaMasao Kakoki
Jun 16, 2015·Frontiers in Endocrinology·Ini-Isabée WitzelHabiba Alsafar
Sep 26, 2013·Diabetes·Peter Rossing, Maria Lajer
Jun 11, 2009·Diabetes Care·Tadashi KonoshitaUNKNOWN Genomic Disease Outcome Consortium (G-DOC) Study Investigators
Oct 20, 2012·Journal of Pharmacological Sciences·Paulo Caleb Junior Lima SantosAlexandre Costa Pereira
Jul 6, 2016·Journal of Translational Medicine·Michelle J PenaHiddo J L Heerspink
Dec 22, 2016·British Journal of Clinical Pharmacology·Sergei I PetrykivHiddo J L Heerspink
Jan 25, 2013·Nephron. Clinical Practice·Isabelle ChapdelaineStéphan Troyanov
Oct 9, 2018·Diabetes, Obesity & Metabolism·Hiddo J L HeerspinkVlado Perkovic
Jul 24, 2008·Nature Clinical Practice. Nephrology·Jesús Egido, Alberto Ortiz
Jun 23, 2018·Journal of the American Society of Nephrology : JASN·Sophie M van den BeltUNKNOWN ESCAPE Trial Group
Mar 22, 2018·Scientific Reports·Sara ContiGiuseppe Remuzzi
Jun 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Piero RuggenentiGiuseppe Remuzzi
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Brad H RovinDaniel J Birmingham
Jan 25, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Stine E NielsenPeter Rossing
Apr 29, 2020·BMJ Open Sport & Exercise Medicine·Kelsley E JoyceArthur Bradwell
Jun 14, 2013·American Journal of Physiology. Renal Physiology·Jan WysockiDaniel Batlle
Sep 17, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Nicolás Roberto RoblesRoman Hernandez-Gallego
Sep 11, 2010·Molecular and Cellular Biochemistry·Vahid FelehgariAsad Vaisi-Raygani
Jun 14, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P Kovesdy
Aug 23, 2020·International Journal of Molecular Sciences·Michele ProvenzanoMichele Andreucci
Feb 22, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·He-Ping LeiXi-Yong Yu
Sep 18, 2016·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yuying WangChenguang Wu
Apr 16, 2021·Endocrinology, Diabetes & Metabolism·Rachel AdamsGiuseppe N Giordano
Jun 22, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sok Cin TyeHiddo J L Heerspink
Apr 1, 2018·Canadian Journal of Diabetes·Lyne Cloutier, Maxime Lamarre-Cliche

❮ Previous
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