ACE gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis

International Journal of Chronic Obstructive Pulmonary Disease
Yao MaHong Fan

Abstract

Angiotensin-converting enzyme (ACE) gene I/D polymorphism has been studied in relation to the susceptibility to COPD and COPD with pulmonary hypertension (PH) with inconclusive results. We performed the first comprehensive meta-analysis to evaluate accurately the association between the ACE gene polymorphism and the risk of COPD. Data were analyzed using odds ratios (ORs) and the corresponding 95% CIs to measure the strength of the models. Subgroup analyses were conducted by ethnicity and complication which referred to PH. In total, 15 studies (2,635 participants) were included in our study, of which four studies (288 participants) were for PH subgroup. The overall analysis results indicated that the ACE gene polymorphism was not associated with COPD susceptibility in all gene models. However, the ethnic subgroup analysis results indicated that ACE gene polymorphism was associated with Asians' susceptibility to COPD (DD+DI vs II, OR=1.47, P=0.019, 95% CI: 1.07-2.02). Further, the overall results of the present study detected no statistical significance between ACE gene polymorphism and the risk of COPD with PH, but the homozygote variant (DD) increased the risk of PH in Asian COPD patients (DD vs ID+II, OR=2.05, P=0.05, 95% CI:...Continue Reading

Citations

May 3, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marie EssigZiad Massy
Apr 29, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Pere AlmagroJesús Recio
Apr 4, 2021·International Journal of Environmental Research and Public Health·Adrián Montes-de-Oca-GarcíaJesús G Ponce-González
Aug 8, 2021·Cancers·Styliani A GeronikolouDennis V Cokkinos

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