ACE inhibitors captopril and enalapril induce regression of left ventricular hypertrophy in hypertensive patients with chronic renal failure

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A I DyadykG G Taradin

Abstract

Left ventricular hypertrophy is frequently noted in patients with moderate to severe chronic renal failure not requiring dialysis. Recently, several studies have shown reversal of myocardial hypertrophy in end-stage renal disease with long-term pharmacological control of blood pressure, but it is unclear whether left ventricular mass regresses or normalizes with antihypertensive treatment of patients with earlier stages of chronic renal failure. Seventy-two undialysed patients with chronic renal failure, chronic mild-to-moderate hypertension, and left ventricular hypertrophy were randomly assigned in a prospective study to either the captopril (n = 36) or enalapril group (n = 36). Blood pressure measurements, echocardiographic and Doppler parameters were evaluated before treatment and at 6 and 12 months of therapy. During follow-up, six patients developed side-effects including dry cough, taste disturbances, skin rash and gastric intolerance. In the captopril group there was a decrease in mean left ventricular mass index by 12% after 6 months of treatment, which decreased by 20% after 12 months treatment. For enalapril, the average reduction of myocardial mass after 6 months treatment was 14% and after 12 months treatment, the ...Continue Reading

Citations

Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·S P McDonaldW E Hoy
May 25, 2002·Kidney International·Christopher T ChanAndreas Pierratos
Apr 8, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter J Blankestijn
Apr 17, 2004·Kidney International·Jutta NeumannPeter J Blankestijn
Jan 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Monte S WillisCam Patterson
Apr 28, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·H SuzukiX M Chen
Apr 16, 2003·The American Journal of the Medical Sciences·Martin A Alpert
Apr 16, 2003·The American Journal of the Medical Sciences·Stephen A MorseEfrain Reisin
Dec 30, 2014·Journal of the Chinese Medical Association : JCMA·Yao-Ping LinChao-Hsiung Lin
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthias P Hörl, Walter H Hörl
Jul 15, 2004·Seminars in Dialysis·Peter J Blankestijn, Gerry Ligtenberg
Dec 7, 2005·The Journal of Clinical Hypertension·Kavitha M ChinnaiyanPeter A McCullough
Mar 29, 2008·American Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Jan 24, 2007·American Heart Journal·Kavitha M ChinnaiyanPeter A McCullough
Jun 6, 2009·Therapeutic Advances in Cardiovascular Disease·Hiromichi Suzuki
May 12, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Timothy W R Doulton, Graham A MacGregor
Feb 4, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Peter A McCulloughMichael P Hudson
Jun 4, 2008·Journal of Cardiovascular Pharmacology·Maurizio Galderisi, Oreste de Divitiis
Feb 28, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Connie L DavisAlan H Wilkinson
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S ErtürkA E Ertuğ
Apr 20, 2021·Clinical and Experimental Hypertension : CHE·Quênia Janaína Tomaz de CastroAndrea Grabe-Guimarães

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