ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats.

Clinical Science
Tatiane Cristine Silva de AlmeidaAna Cristina Simões E Silva

Abstract

Acute Kidney Injury (AKI) comprises a rapidly developed renal failure and is associated with high mortality rates. The Renin-Angiotensin System (RAS) plays a pivotal role in AKI, as the over-active RAS axis exerts major deleterious effects in disease progression. In this sense, the conversion of Angiotensin II (Ang II) into Angiotensin-(1-7) (Ang-(1-7)) by the Angiotensin-converting enzyme 2 (ACE2) is of utmost importance to prevent worse clinical outcomes. Previous studies reported the beneficial effects of oral diminazene aceturate (DIZE) administration, an ACE2 activator, in renal diseases models. In the present study, we aimed to evaluate the therapeutic effects of DIZE administration in experimental AKI induced by gentamicin (GM) in rats. Our findings showed that treatment with DIZE improved renal function and tissue damage by increasing Ang-(1-7) and ACE2 activity, and reducing TNF-α. These results corroborate with a raising potential of ACE2 activation as a strategy for treating AKI.

References

Feb 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N PapanikolaouJ Bariety
Jan 1, 1988·Methods in Enzymology·P J Bailey
Sep 1, 2000·Regulatory Peptides·R A SantosS P Andrade
Jun 15, 2001·Kidney International·P K ChatterjeeC Thiemermann
Feb 19, 2004·The American Journal of Medicine·Ursula C Brewster, Mark A Perazella
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
May 25, 2006·Mini Reviews in Medicinal Chemistry·Ana Cristina Simões e SilvaRobson Augusto Souza Santos
Sep 8, 2006·Journal of Hypertension·Els A van der WoudenRobert H Henning
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Christiane Rüster, Gunter Wolf
Oct 20, 2006·Cardiovascular Research·Shlomo KeidarAviva Gamliel-Lazarovich
Feb 22, 2007·Kidney & Blood Pressure Research·Eun Hui BaeSoo Wan Kim
Jul 3, 2007·Toxicology and Applied Pharmacology·Carlos Martínez-SalgadoJosé M López-Novoa
Jul 25, 2008·Kidney International·Detlef O Schlondorff
Jul 7, 2009·TheScientificWorldJournal·Marc Dilauro, Kevin D Burns
Feb 5, 2010·The American Journal of Cardiology·Jeffrey L Probstfield, Kevin D O'Brien
May 4, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarArunachalam Thangathirupathi
Oct 22, 2010·American Journal of Physiology. Renal Physiology·Jorge F GianiFernando P Dominici
Nov 19, 2010·Postgraduate Medicine·Devasmita Choudhury
Feb 10, 2012·International Journal of Hypertension·Lívia Corrêa BarrosoMauro Martins Teixeira
Jul 20, 2012·Nephron Extra·Viviane Gomes PortellaMaria Aparecida Ribeiro Vieira
Aug 3, 2012·Kidney International·Man JiangZheng Dong
Mar 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Stuart L GoldsteinUNKNOWN Acute Kidney Injury Advisory Group of American Society of Nephrology
Apr 24, 2013·Hypertension·Rodrigo A Fraga-SilvaAnderson J Ferreira
Jan 22, 2014·Nature Reviews. Nephrology·Oleksa Rewa, Sean M Bagshaw
Dec 6, 2014·Advances in Preventive Medicine·Maryam Malek, Mehdi Nematbakhsh
Mar 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ana Cristina Simões E Silva, Mauro Martins Teixeira
Apr 30, 2016·Indian Journal of Pharmacology·Vamsi SodimbakuSaisudheer Marri
Apr 6, 2019·Protein and Peptide Letters·Lucas Miranda KangussuAnderson José Ferreira
Oct 24, 2019·Clinical and Experimental Pharmacology & Physiology·Julliane V Joviano-SantosAnderson J Ferreira

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Citations

Apr 4, 2021·Journal of Clinical Medicine·Samuel N HeymanZaid Abassi

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