ACE2 and Microbiota: Emerging Targets for Cardiopulmonary Disease Therapy

Journal of Cardiovascular Pharmacology
Colleen T Cole-JeffreyVinayak Shenoy

Abstract

The health of the cardiovascular and pulmonary systems is inextricably linked to the renin-angiotensin system (RAS). Physiologically speaking, a balance between the vasodeleterious (Angiotensin-converting enzyme [ACE]/Angiotensin II [Ang II]/Ang II type 1 receptor [AT1R]) and vasoprotective (Angiotensin-converting enzyme 2 [ACE2]/Angiotensin-(1-7) [Ang-(1-7)]/Mas receptor [MasR]) components of the RAS is critical for cardiopulmonary homeostasis. Upregulation of the ACE/Ang II/AT1R axis shifts the system toward vasoconstriction, proliferation, hypertrophy, inflammation, and fibrosis, all factors that contribute to the development and progression of cardiopulmonary diseases. Conversely, stimulation of the vasoprotective ACE2/Ang-(1-7)/MasR axis produces a counter-regulatory response that promotes cardiovascular health. Current research is investigating novel strategies to augment actions of the vasoprotective RAS components, particularly ACE2, in order to treat various pathologies. Although multiple approaches to increase the activity of ACE2 have displayed beneficial effects against experimental disease models, the mechanisms behind its protective actions remain incompletely understood. Recent work demonstrating a non-catalytic ...Continue Reading

References

May 4, 1978·The New England Journal of Medicine·H GavrasD N McKinstry
Sep 1, 1993·Acta Tropica·A S Peregrine, M Mamman
Apr 4, 2000·European Journal of Clinical Nutrition·L Agerholm-LarsenA Astrup
Jan 11, 2000·European Journal of Clinical Nutrition·L Agerholm-LarsenA Astrup
Feb 16, 2002·International Journal of Food Microbiology·Tiiu KullisaarAnn Kilk
Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Nov 27, 2002·The American Journal of Clinical Nutrition·Marek NaruszewiczHanna Bukowska
Jan 24, 2003·The American Journal of Clinical Nutrition·Leena SeppoRiitta Korpela
May 2, 2003·Molecular Biotechnology·John E Hall
Jan 13, 2004·Experimental Dermatology·Kathleen E RodgersGere diZerega
May 21, 2004·BMC Medicine·Andrew B GoulterKenneth L Clark
Aug 18, 2004·Circulation·Danilo FliserUNKNOWN EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators
Mar 24, 2005·Journal of Cellular and Molecular Medicine·Panagiotis KougiasChangyi Chen
Jun 14, 2005·American Journal of Physiology. Heart and Circulatory Physiology·E Ann TallantPatricia E Gallagher
Aug 6, 2005·Nutrition Journal·Epp SongiseppMarika Mikelsaar
Aug 12, 2005·Journal of the American College of Nutrition·Kotaro AiharaYasunori Nakamura
Nov 12, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wolfgang LiebJeanette Erdmann
Jan 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Justin L GrobeMichael J Katovich
Apr 29, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Kristina EdfeldtZhong-qun Yan
Jun 21, 2006·The American Journal of Cardiology·Carlos M Ferrario, William B Strawn
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Jul 28, 2006·American Journal of Physiology. Cell Physiology·Puja K Mehta, Kathy K Griendling
Sep 1, 2006·Food Microbiology·Yi-Chieh WangCheng-Chun Chou
Sep 12, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Montserrat BatlleWladimiro Jimenez
Sep 27, 2006·The American Journal of Medicine·Andrea GalassiJiang He
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Justin L GrobeMichael J Katovich
Dec 15, 2006·Nature·Ursula DanilczykJosef M Penninger

❮ Previous
Next ❯

Citations

Apr 11, 2018·American Journal of Respiratory and Critical Care Medicine·Elaine M Richards, Mohan K Raizada
Dec 3, 2016·The Journal of Pharmacology and Experimental Therapeutics·Glen Stephen Patten, Mahinda Yapa Abeywardena
Oct 6, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christy S CarterThomas W Buford
Jun 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Silan GuLanjuan Li
Aug 14, 2020·International Journal of Food Sciences and Nutrition·Benedetta BottariErasmo Neviani
Apr 15, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Allegra Battistoni, Massimo Volpe
Jun 26, 2020·Frontiers in Microbiology·Li-Hong HeLei Zhang
Feb 14, 2021·Physiological Reports·Aline Vasques da CostaPatrícia Gama
Dec 22, 2020·Frontiers in Medicine·Francesca SalamannaMilena Fini
Dec 31, 2020·International Journal of Molecular Sciences·Yuanpeng ZhengAletta D Kraneveld
Nov 17, 2020·Journal of Community Hospital Internal Medicine Perspectives·Anwaruddin SyedSonu Dhillon
Dec 8, 2020·Therapeutic Advances in Gastroenterology·Jonathan P SegalJulian R Marchesi
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elena Barengolts, Emily Daviau Smith
Jan 23, 2021·Medical Hypotheses·Seyed Aria NejadghaderiHamid Asadzadeh Aghdaei
Nov 26, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Girish PathangeyAmr E Abbas
Oct 17, 2020·Clinical Science·Qiuhong LiMohan K Raizada
Aug 23, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Sonia Villapol
Apr 2, 2021·Frontiers in Cardiovascular Medicine·Yang YiJun Wang
Apr 1, 2021·Archives of Medical Research·Shilia Jacob KurianMahadev Rao
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Indranil Chattopadhyay, Esaki M Shankar
May 7, 2021·Mediators of Inflammation·Sara Ahmadi BadiSeyed Davar Siadat
Apr 16, 2021·The American Journal of Chinese Medicine·Qiao ZhangYuping Tang
May 14, 2021·Journal of Neurovirology·Mina GholamiMajid Motaghinejad
May 11, 2021·Frontiers in Cellular and Infection Microbiology·Ramachandran VigneshSripathi M Sureban
May 21, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jie YinTongda Xu
Jun 11, 2021·Inflammopharmacology·Puneet KumarSumit Jamwal
May 22, 2020·Diabetes & Metabolic Syndrome·Marko MarhlRene Markovič
Jun 29, 2021·Journal of the National Medical Association·Nabil A FallouhJuan A Reyes
Jul 27, 2021·Saudi Journal of Biological Sciences·Ibrahim TaherThangavel Alphonse Thanaraj
Apr 20, 2020·Biochimie·Marco AlifanoAntonio Iannelli
Mar 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soonho KwonGeun Hee Seol
Nov 6, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Santosh Shenoy
Jun 7, 2021·Journal of Cardiovascular Medicine·Pasquale PagliaroClaudia Penna

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