ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19

Journal for Immunotherapy of Cancer
Riyue BaoJason John Luke

Abstract

Pandemic COVID-19 by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection is facilitated by the ACE2 receptor and protease TMPRSS2. Modestly sized case series have described clinical factors associated with COVID-19, while ACE2 and TMPRSS2 expression analyses have been described in some cell types. Patients with cancer may have worse outcomes to COVID-19. We performed an integrated study of ACE2 and TMPRSS2 gene expression across and within organ systems, by normal versus tumor, across several existing databases (The Cancer Genome Atlas, Census of Immune Single Cell Expression Atlas, The Human Cell Landscape, and more). We correlated gene expression with clinical factors (including but not limited to age, gender, race, body mass index, and smoking history), HLA genotype, immune gene expression patterns, cell subsets, and single-cell sequencing as well as commensal microbiome. Matched normal tissues generally display higher ACE2 and TMPRSS2 expression compared with cancer, with normal and tumor from digestive organs expressing the highest levels. No clinical factors were consistently identified to be significantly associated with gene expression levels though outlier organ systems were observed for some ...Continue Reading

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Citations

Feb 21, 2021·Journal of Cellular and Molecular Medicine·Jingliang ChengChunli Wei
Mar 12, 2021·BMJ : British Medical Journal·Amy H AttawayUmur Hatipoğlu
Mar 20, 2021·World Journal of Gastrointestinal Oncology·Xiao-Sheng Wang
Aug 19, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kinga JaworskaMarcin Ufnal

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Methods Mentioned

BETA
RNAseq
RNA-Seq
scRNAseq
single-cell sequencing

Software Mentioned

Bioconductor
OptiType
LASSO
LAML
R
xCell

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