ACE2 as therapy for glomerular disease: the devil is in the detail

Kidney International
Michael J Ross, Masaomi Nangaku

Abstract

Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.

References

Nov 26, 2009·Diabetes·Gavin Y OuditJames W Scholey
Nov 18, 2015·Current Opinion in Nephrology and Hypertension·David I Ortiz-Melo, Susan B Gurley

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Citations

Sep 21, 2017·Current Hypertension Reports·Silas CulverHelmy M Siragy
Sep 19, 2019·Toxicology Mechanisms and Methods·Runali SankheMadhavan Nampoothiri
May 30, 2020·Acta Physiologica·Alonso MarquezDaniel Batlle
May 31, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heleia Roca-HoMarta Riera
Aug 9, 2019·International Journal of Molecular Sciences·Sang Heon SuhEun Hui Bae
Nov 3, 2020·Clinical Science·Enrique LoresDaniel Batlle

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