ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19

The Journal of Infectious Diseases
Bruna G G PintoHelder I Nakaya

Abstract

Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes, and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV-2 to bind and enter host cells, no study has systematically assessed the ACE2 expression in the lungs of patients with these diseases. Here, we analyzed over 700 lung transcriptome samples from patients with comorbidities associated with severe COVID-19 and found that ACE2 was highly expressed in these patients compared to control individuals. This finding suggests that patients with such comorbidities may have higher chances of developing severe COVID-19. Correlation and network analyses revealed many potential regulators of ACE2 in the human lung, including genes related to histone modifications, such as HAT1, HDAC2, and KDM5B. Our systems biology approach offers a possible explanation for increased COVID-19 severity in patients with certain comorbidities.

References

Jan 29, 1999·Lancet·B Marc, F Baud
Feb 13, 2001·The Journal of Pathology·M H VaaralaP T Vihko
Nov 24, 2005·Life Sciences·Xudong XieLiu Yanrong
May 15, 2007·Bioinformatics·Sean Davis, Paul S Meltzer
May 5, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hong Peng JiaPaul B McCray
May 21, 2009·Nature Reviews. Endocrinology·Fengxia LiangDaisuke Koya
Oct 2, 2009·Clinical and Experimental Pharmacology & Physiology·Mao-liang HuangZhen-shu Zhang
Dec 1, 2011·Nature Methods·Xin ZhouTing Wang
Apr 17, 2013·BMC Bioinformatics·Edward Y ChenAvi Ma'ayan
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Apr 4, 2015·International Journal of Genomics·Woo Jin KimYeon-Mok Oh
Jun 2, 2017·World Journal of Gastroenterology : WJG·Xuyang WangShuichi Kaneko
Jul 12, 2017·Small GTPases·Paul Spearman
Jan 22, 2019·Reviews in Medical Microbiology : a Journal of the Pathological Society of Great Britain and Ireland·Antonio TonioloEle Ferrannini
Mar 22, 2019·Frontiers in Genetics·Lucas E CardozoHelder I Nakaya
May 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simone PippaRodolfo Negri
May 23, 2019·Nucleic Acids Research·Chih-Hsuan WeiZhiyong Lu
Aug 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Diógenes S de LimaHelder I Nakaya
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Mar 23, 2020·The Lancet Infectious Diseases·Yang LiuWei Zhang
Mar 29, 2020·The New England Journal of Medicine·Alexandre P Zavascki, Diego R Falci

❮ Previous
Next ❯

Citations

May 20, 2020·The FEBS Journal·Oleg O Glebov
Jul 17, 2020·Frontiers in Immunology·Luiz G GardinassiSimone G Fonseca
Aug 12, 2020·Cellular and Molecular Life Sciences : CMLS·Jie WuXiuhong Yang
Sep 19, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ricardo Wesley Alberca
Aug 8, 2020·Clinical Epigenetics·Ranim El Baba, Georges Herbein
Jul 21, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Sarantis ChlamydasChristina Piperi
Aug 31, 2020·Immunology and Cell Biology·Shahin HallajFarhad Jadidi-Niaragh
Jun 12, 2020·International Journal of Cancer. Journal International Du Cancer·Tom Winkler, Uri Ben-David
Oct 17, 2020·Annals of Laboratory Medicine·Sarita ChoudharyPraveen Sharma
Nov 10, 2020·ELife·Natalia Zamorano Cuervo, Nathalie Grandvaux
Nov 12, 2020·Oral Diseases·Lakshman Perera SamaranayakeHien Chi Ngo
Dec 5, 2020·Genetics and Molecular Biology·Patricia NolascoLygia Veiga Pereira
Nov 10, 2020·Journal of Internal Medicine·J M Carethers
Oct 22, 2020·Genome Génome / Conseil National De Recherches Canada·Tasnim H BeaconJames R Davie
Dec 18, 2020·Frontiers in Physiology·Caio A M TavaresAdriana C C Girardi
Jan 4, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Stephany BeyerstedtÉrika Bevilaqua Rangel
Jan 7, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Shreya Mukherjee, Kalipada Pahan
Sep 29, 2020·Computational and Structural Biotechnology Journal·Ratul ChowdhuryCostas D Maranas
Jan 5, 2021·Current Opinion in Nephrology and Hypertension·Luca PericoGiuseppe Remuzzi
Feb 4, 2021·Genetics and Molecular Biology·Joel Henrique EllwangerJosé Artur Bogo Chies
Oct 28, 2020·American Journal of Clinical Pathology·Maxwell D WeidmannAlex J Rai
Jan 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Murat Oz, Dietrich Ernst Lorke
Feb 16, 2021·Journal of Biomolecular Structure & Dynamics·Francesco OrtusoFederico Manuel Giorgi
Jan 1, 2021·Cell & Bioscience·Miriam Marlene Medina-EnríquezTalia Wegman-Ostrosky
Jan 6, 2021·Viruses·Aisha D FakhrooHadi M Yassine
Dec 30, 2020·Scientific Reports·Min YeeMichael A O'Reilly
Jan 15, 2021·Open Heart·Farhan ChaudhryPhillip Levy
Jan 17, 2021·Trends in Microbiology·Rahul K SuryawanshiDeepak Shukla
Feb 16, 2021·Frontiers in Immunology·Thais Fernanda de Campos Fraga-SilvaVânia Luiza Deperon Bonato
Dec 11, 2020·Journal of Immunology Research·Fernanda Dos AnjosMargarete Dulce Bagatini
Jan 31, 2021·Human Genomics·Sally Badawi, Bassam R Ali
Nov 17, 2020·Frontiers in Molecular Biosciences·Federica SaponaroRiccardo Zucchi
Oct 16, 2020·Hematology/oncology and Stem Cell Therapy·Muhammad Bilal AbidMehdi Hamadani
Nov 26, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Girish PathangeyAmr E Abbas
Mar 3, 2021·Genetics and Molecular Biology·Michel Satya NaslavskyMayana Zatz
Apr 3, 2021·Clinical Kidney Journal·Jordana B CohenMatthew A Sparks

❮ Previous
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