ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain

Journal of Medical Virology
Laura Torre-FuentesJordi A Matías-Guiu

Abstract

It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently available. This study addresses the apparently reasonable hypothesis that variants of these genes may modulate viral infectivity, making some individuals more vulnerable than others. Through whole-exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to presence or absence of SARS-CoV-2 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. The ACE2 gene showed a low level of polymorphism, and none variant was significantly associated with SARS-CoV-2 infection. These variants have previously been detected in Italy. While TMPRSS2 is highly polymorphic, the variants found do not coincide with those described in other studies, with the exception of rs75603675, which may be associated with SARS-CoV-2 infection. The synonymous variants rs61735792 and rs61735794 showed a significant association with infection. Despite the limite...Continue Reading

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Citations

Sep 29, 2020·Frontiers in Immunology·Inmaculada Sanclemente-AlamanUlises Gómez-Pinedo
Oct 9, 2020·IUBMB Life·Vignesh MariappanAgieshkumar Balakrishna Pillai
Nov 5, 2020·Biomedicines·Alessandro MatareseGaetano Santulli
Feb 17, 2021·Cell Biology International·Zafer YildirimVildan Bozok Cetintas
May 3, 2021·Archives of Virology·Seyed Mohammad Ali HashemiJamal Sarvari
May 22, 2021·European Journal of Medical Research·SeyedAhmad SeyedAlinaghiFabricio Voltarelli
Aug 9, 2021·Current Opinion in Virology·Christian S StevensBenhur Lee
Aug 24, 2021·Immunobiology·Juliana M SerpeloniLuciane R Cavalli
Aug 31, 2021·Heliyon·I KaidashevD Maryniak

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
PLINK

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