ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review.

Head and Neck Pathology
Jerome R LechienSven Saussez

Abstract

To review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue. Scopus, Cochrane Library, Medrxiv, Google Scholar and PubMED/MEDLINE were searched by four independent investigators for studies investigating ACE2 or TMPRSS2 expressions in head and neck tissues. The following outcomes were considered: sample origin (animal versus human); detection method; anatomical location and cell types. PRISMA checklist and modified population, intervention, comparison, outcome, timing and setting (PICOTS) framework were used to perform the review. Of the 24 identified studies, 17 met our inclusion criteria. Thirteen studies were conducted during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. ACE2 and TMPRSS2 were expressed in oral, pharyngeal, sinusonasal human mucosa. The following cell types expressed ACE2: basal, apical, goblet, minor salivary, and endothelial cells. TMPRSS2 was found in goblet and apical respiratory cells. ACE2 and TMPRSS2 were found in the olfactory region, especially in sustentacular non-neural and neural stem cells. Animal studies suggested that ACE2 expression may vary regarding age. There was an i...Continue Reading

References

Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Sep 7, 2016·Nature Methods·Mathias UhlenTadashi Yamamoto
May 31, 2017·The Laryngoscope·Annachiara CavazzanaThomas Hummel
Jan 25, 2018·JAMA : the Journal of the American Medical Association·Matthew D F McInnesBrian H Willis
Feb 26, 2020·International Journal of Oral Science·Hao XuQianming Chen
Apr 3, 2020·The Laryngoscope·Luigi Angelo VairaGiacomo De Riu
Apr 8, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Apr 10, 2020·Journal of Dental Research·J XuY Yao
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Giacomo SpinatoPaolo Boscolo-Rizzo
Apr 25, 2020·Nature Medicine·Waradon SungnakUNKNOWN HCA Lung Biological Network
Apr 29, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rachel KayeJames C Denneny
Apr 30, 2020·Infectious Diseases of Poverty·Meng-Yuan LiXiao-Sheng Wang
May 1, 2020·Journal of Internal Medicine·Jerome R LechienUNKNOWN COVID-19 Task Force of YO-IFOS
May 6, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Pasquale CapaccioSara Torretta
May 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jian ShangFang Li
May 21, 2020·JAMA : the Journal of the American Medical Association·Katherine Lisa Whitcroft, Thomas Hummel
May 24, 2020·Neurology·Thomas LaurendonArthur Varoquaux
Jun 4, 2020·Emerging Infectious Diseases·Jerome R LechienRobert Carlier
Jul 1, 2020·Journal of Voice : Official Journal of the Voice Foundation·Jerome R LechienSven Saussez

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Citations

Oct 6, 2020·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Luigi Angelo VairaGiacomo De Riu
Nov 11, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·José VergaraLúcia Figueiredo Mourão
Nov 17, 2020·The Journal of Laryngology and Otology·L A VairaG De Riu
Jul 1, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Alberto Martin-MartinezPere Clavé

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Methods Mentioned

BETA
RNAseq

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