PMID: 338101Nov 12, 1977Paper

Acebutolol, atenolol, and propranolol and metabolic responses to acute hypoglycaemia in diabetics

British Medical Journal
S P DeaconD Barnett

Abstract

In a double-blind crossover study the symptomatic and metabolic effects of propranolol, acebutolol, and atenolol were studied during insulin-induced hypoglycaemia in diabetics treated with diet or hypoglycaemic tablets. All the drugs prevented tachycardia, but did not affect the other symptoms of hypoglycaemia. Propranolol delayed the recovery of the blood glucose concentration and impaired the secondary rise in the concentrations of blood lactate and non-esterified fatty acids in diet-treated diabetics. Acebutolol potentiated the hypoglycaemic effect of insulin in tablet-treated diabetics (mean difference of blood glucose concentration 0.7 mmol/l (12.6 mg/100 ml)) and this difference was maintained during the recovery phase4 the blood lactate response was also impaired. Atenolol did not differ perceptibly from placebo in its effect on the metabolic responses to acute hypoglycaemia. The results may be explained by differences in the known pharmacological actions of these drugs. They support the hypothesis that beta-adrenoreceptor blocking drugs that are highly beta1 specific and without membrane-stabilising activity should be safer than the non-selective drugs when used in diabetic patients at risk from hypoglycaemia.

References

Jul 31, 1976·British Medical Journal·S P Deacon, D Barnett
Jul 17, 1976·The Medical Journal of Australia
Dec 24, 1966·Lancet·M N KotlerA H Rubenstein

Citations

Apr 1, 1979·Diabetologia·N J Christensen
Sep 22, 1995·Pharmacy World & Science : PWS·L BergendalA Schaffrath
Jan 1, 1980·Pharmacology & Therapeutics·B N Prichard, C W Owens
Jan 1, 1983·Pharmacology & Therapeutics·A J Scriven, P J Lewis
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Mar 19, 2004·The Journal of Emergency Medicine·Jeffrey N Love, Neal Sikka
Nov 1, 1981·Clinics in Endocrinology and Metabolism·J R Sowers, M L Tuck
Apr 6, 2002·Reproductive Toxicology·Sonia A Tabacova, Carole A Kimmel
Jul 17, 2001·Journal of Internal Medicine·P T Sawicki, A Siebenhofer
Jun 17, 1982·The New England Journal of Medicine·W H Frishman
Apr 5, 1980·British Medical Journal·A H BarnettP J Watkins
Oct 25, 1980·British Medical Journal·U SmithP Lönnroth
Jul 1, 1985·Postgraduate Medical Journal·A D Struthers
Aug 18, 2006·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Britt KveiborgChristian Torp-Pedersen
Aug 19, 2007·Journal of Cardiovascular Medicine·Donatella Del SindacoFrancesco Leggio
Jan 1, 1986·Current Medical Research and Opinion·D M FraserJ D Poloniecki
Sep 26, 2008·Psychoneuroendocrinology·Min Jung ParkGregory G Freund
May 1, 1985·American Heart Journal·G De BonoA J Summers
Apr 26, 1985·The American Journal of Cardiology·L H Opie
Nov 1, 1985·Hypertension·B N TrostC Beretta-Piccoli
Nov 1, 1985·Anaesthesia·R I MeekeJ D Gaffney
Apr 1, 1982·British Journal of Clinical Pharmacology·R ZamanP I Biggs
Jun 20, 2006·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Vicki Oldfield, Katherine A Lyseng-Williamson
Oct 1, 1979·Scottish Medical Journal·D G Lambie
Apr 1, 1985·Drug Intelligence & Clinical Pharmacy·G A Mills, J R Horn
Jul 1, 1979·Scottish Medical Journal·L E Ramsay
May 1, 1982·Acta Medica Scandinavica·K KølendorfB Broch-Møller
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell
Dec 16, 2020·Diabetes, Obesity & Metabolism·Dsh Bell, E Goncalves

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.