Acebutolol in hypertension--double-blind trial against placebo

British Journal of Clinical Pharmacology
M A MartinA J Smith


1. Eleven hypertensive patients were studied in a double-blind comparison of acebutolol, a beta-adrenoceptor blocker, and placebo. 2. Optimum dosage defined in an open assessment varied from 200--600 mg twice daily. 3. Blood pressure and pulse rate fell significantly while patients were lying, standing and after exercise. 4. Blood pressure remained as well controlled on each patient's optimum daily dose when taken once daily, and assessed 24 h post dose. 5. There was no correlation between blood pressure reduction and changes in heart rate. On once daily therapy while blood pressure remained unchanged at 24 h post dose there was a signficant reduction in beta-adrenoceptor blockade as measured by percentage reduction in exercise tachycardia. 6. There was no significant change in urinary catecholamine excretion or echocardiographically estimated cardiac output. 7. A correlation was found between the change in plasma renin activity (log transformed) and blood pressure reduction.


Jul 3, 1976·British Medical Journal·C DavidsonS H Taylor
May 20, 1976·The New England Journal of Medicine·J W WoodsC A Allen
May 1, 1976·British Medical Journal·M H Frick, P Pörsti
Jan 1, 1976·Current Medical Research and Opinion·W L Ashton
Jan 1, 1976·Current Medical Research and Opinion·R Gabriel
Apr 1, 1975·The American Journal of Cardiology·R L PoppD C Harrison
Jan 1, 1975·European Journal of Clinical Pharmacology·P BironG Tremblay
May 20, 1976·The New England Journal of Medicine·G H Williams
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Jan 12, 1974·British Medical Journal·G S StokesI R Thornell
Mar 1, 1973·Clinical Science·M M Townshend, A J Smith
Mar 1, 1968·Circulation·E D FrohlichI H Page
Oct 1, 1968·The Journal of Clinical Investigation·V DeQuattro, A Sjoerdsma
Dec 1, 1976·British Journal of Clinical Pharmacology·S G CarruthersD G McDevitt

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Dec 18, 1978·European Journal of Clinical Pharmacology·M A MartinA J Smith
Jan 1, 1983·Pharmacology & Therapeutics·A J Scriven, P J Lewis
Feb 1, 1986·International Journal of Cardiology·P A Crean, D O Williams
Feb 1, 1980·British Journal of Clinical Pharmacology·R D WatsonW A Littler
Feb 1, 1982·British Journal of Clinical Pharmacology·P A MitenkoJ J Brossard
Jan 1, 1979·The Journal of International Medical Research·P G Baker, J Goulton
Sep 1, 1983·British Journal of Clinical Pharmacology·R S SmithC F George
Sep 1, 1980·British Journal of Clinical Pharmacology·M A Martin

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