Acebutolol, metoprolol and propranolol in conscious dogs with chronic heart-block: chronotropic effects and relation between depression of ventricular activity and beta-adrenoceptor blocking potency

British Journal of Pharmacology
M Boucher, P Duchêne-Marullaz

Abstract

1 Atrial and ventricular chronotropic effects of acebutolol, metoprolol and propranolol were studied in conscious dogs with chronic heart-block. Ventricular beta-adrenoceptor blocking activity was assessed for the three dogs against isoprenaline (1 microgram/kg) under the same experimental conditions. 2 Acebutolol and metoprolol significantly increased atrial rate. The effect was proportional to the dose for acebutolol, independent for metoprolol. Propranolol had no significant effect on atrial rate. All three drugs significantly lowered ventricular rate in proportion to the dose. 3 Ventricular beta-blocking potencies of metoprolol and acebutolol were respectively 2 and 3 times weaker than that of propranolol as indicated by ED50 values. 4 The ventricular depressor effect observed was proportional to the degree of ventricular beta-blockade present, although this may not be the only factor involved.

References

Feb 1, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·B AbladL Ek
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Nov 1, 1972·The Journal of Pharmacy and Pharmacology·J R Baird, J Linnell
Jan 1, 1973·The American Journal of Physiology·J L RobinsonG Grupp

❮ Previous
Next ❯

Citations

Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M BoucherP Duchêne-Marullaz
Dec 1, 1982·Pflügers Archiv : European journal of physiology·M BoucherP Duchene-Marullaz
Apr 1, 1985·Journal of Pharmacological Methods·M Boucher, P Duchene-Marullaz
Feb 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·N MoinsP Gachon
Nov 20, 2015·British Journal of Anaesthesia·S B DimmittM J Paech
Jun 21, 2019·British Journal of Clinical Pharmacology·Hans G StampferSimon B Dimmitt
Jun 21, 2019·British Journal of Clinical Pharmacology·Simon B DimmittRobin E Ferner
Sep 1, 1986·British Journal of Pharmacology·M BoucherJ L Moundanga

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.