PMID: 8588120Jan 1, 1995Paper

Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis

Rheumatology International
E Martín-MolaJ J Ansoleaga

Abstract

The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis. One hundred and sixty-nine patients, aged between 22 and 70 years, were included in the study. Patients were randomly assigned to two treatment groups; either aceclofenac 100 mg b.i.d. (87 patients) or ketoprofen 50 mg t.i.d. (82 patients). A placebo tablet was administered to aceclofenac-treated patients to maintain the double-blind conditions of the study. Patients were examined at 15 days and at 1, 2 and 3 months. Efficacy was assessed by the following clinical parameters: Ritchie index, pain on a visual analogue scale, grip strength, morning stiffness, spontaneous morning pain, pain on movement and nocturnal pain, together with functional capacity. Efficacy was demonstrated for both drugs, with progressive improvement in the main clinical evaluation parameters until the end of the treatment period. This was particularly pronounced at 15 days in the aceclofenac group, with a rapid improvement in the Ritchie index (baseline vs 15 days: P < 0.001). Laboratory analyses performed...Continue Reading

References

Jan 1, 1991·Scandinavian Journal of Rheumatology·M J WijnandsL B van De Putte
Jan 1, 1989·Scandinavian Journal of Rheumatology. Supplement·S Arone
Jan 1, 1989·Scandinavian Journal of Rheumatology. Supplement·L EjstrupL Petersen
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Apr 28, 1986·The American Journal of Medicine·D W ScholerA Schweizer
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN

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Citations

Jul 1, 1996·Clinical Rheumatology·J A HunterX G Balaguer
May 7, 2008·AAPS PharmSciTech·Ashok R Patel, Vishal Y Joshi
Aug 19, 2005·International Journal of Pharmaceutics·Chul Soon YongHan-Gon Choi
May 28, 2004·Expert Opinion on Pharmacotherapy·Erik Legrand
Nov 1, 2008·Early Intervention in Psychiatry·GeumSook ShimJun Soo Kwon
Jul 22, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Rashmi Ranjan DasNishanth Dev

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