Abstract
The authors aimed to explore the feasibility and safety of an advanced, acellular, flowable wound matrix (FWM) in patients with diabetes-related cavity or tunnel lesions involving deep structures. Patients with diabetic foot ulcers were hospitalized at the General and Geriatric Surgery Unit of the University of Campania in Naples, Italy, between March 2015 and December 2015. Twenty-three patients with tunneled or cavity ulcers were treated. The lesions were filled with the FWM. Surgical wound edges were either approximated with stitches or left to heal by secondary intention. After 6 weeks, 78.26% of patients completely healed after a single application of the FWM. The healing time for all healed wounds was 30.85 ± 12.62 days, or 26.11 ± 5.43 days in patients for whom wound edges were approximated by stitches, and 57.66 ± 3.05 days in the patients who healed by secondary intention (P = .01). Permanent tissue regeneration was observed in a high percentage of patients, and shorter healing time was achieved. Study authors observed a low rate of complications such as major amputation and increased hospitalization. The FWM seems ideal for tunneled and cavity ulcers with irregular geometry. This new porous matrix allows closure of th...Continue Reading
References
Nov 1, 1994·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·E L Feldman, M J Stevens
Jun 23, 2001·Plastic and Reconstructive Surgery·N S MoiemenJ D Frame
Jul 24, 2002·Diabetologia·R LobmannH Lehnert
Nov 22, 2002·The Journal of Surgical Research·Nicole S GibranJohn E Olerud
May 27, 2004·The American Journal of Pathology·Robert D GalianoGeoffrey C Gurtner
Mar 5, 2005·Journal of Diabetes and Its Complications·Edgar J G PetersDavid G Armstrong
Nov 18, 2005·Lancet·Vincent Falanga
Mar 2, 2006·The American Journal of Pathology·Itamar GorenStefan Frank
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Sep 26, 2006·Tissue Engineering·M Ehrenreich, Z Ruszczak
Oct 4, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hanna GalkowskaWaldemar L Olszewski
Mar 30, 2007·The American Journal of Pathology·Kazuichi MaruyamaPatricia A D'Amore
Sep 29, 2007·Advanced Drug Delivery Reviews·Florian RehfeldtDennis E Discher
Feb 4, 2009·Skin Pharmacology and Physiology·L Macri, R A F Clark
Feb 14, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Silvestro CanonicoAndrea Fattopace
Oct 30, 2009·Journal of the Royal Society, Interface·Rostislav V ShevchenkoS Elizabeth James
Aug 25, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Vickie R DriverKevin C Chung
May 13, 2017·Updates in Surgery·F CampitielloS Canonico
Citations
Mar 27, 2021·Archives of Plastic Surgery·Sara TaniniGiulia Lo Russo
Jul 3, 2021·International Journal of Molecular Sciences·Ferdinando CampitielloSilvestro Canonico
Jul 14, 2021·Journal of Diabetes Investigation·Paola CarusoKatherine Esposito
Aug 13, 2021·Journal of Wound Care·Marcella CammarotaSilvestro Canonico