Acellular implantable and injectable hydrogels for vascular regeneration

Biomedical Materials
Michael R Blatchley, Sharon Gerecht

Abstract

In recent years, therapeutic angiogenesis has been sought as a treatment for many vascular disorders, including peripheral artery disease and coronary artery disease. As mechanisms of angiogenesis and vasculogenesis have been elucidated, the functions of important growth factors and cytokines have been identified. Bolus injections of these growth factors have had limited clinical success because of their short half-lives and difficulty controlling their systemic effects. Over the last 15 years, many hydrogel technologies have been developed to help solve these issues. Many of these hydrogel technologies have aimed to conjugate pro-angiogenic growth factors with controlled, local delivery. However, in order to attain maximum therapeutic effects, multiple growth factors are necessary, owing to the complex nature of the angiogenic pathway. While many groups have successfully conjugated growth factors controlling different steps of angiogenesis, clinical success remains elusive and will likely rely on both spatial and temporal control over growth factor release as these systems evolve in the future. A number of physical factors of the microenvironment also play a vital role in regulating angiogenesis, including ultrastructure, degr...Continue Reading

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Citations

Nov 20, 2015·Expert Opinion on Biological Therapy·Gabor M Rubanyi
Jun 9, 2016·Tissue Engineering. Part a·Paul H LiebesnyAlan J Grodzinsky
Dec 23, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Michael BlatchleySharon Gerecht
Jun 13, 2015·Biomedical Materials·Milica Radisic
Apr 12, 2018·American Journal of Respiratory Cell and Molecular Biology·Matthew D McGrawSteven H Abman
Aug 20, 2019·Advanced Drug Delivery Reviews·Zhao WeiSharon Gerecht
Jan 31, 2020·Biomaterials·D GholobovaL Thorrez
Oct 24, 2020·Biomedicines·Maria Vittoria GiraudoFrancesca Boccafoschi
Mar 16, 2016·Biotechnology Advances·Mohammadmajid SepantafarHossein Baharvand

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