Acellular pertussis vaccines. Towards an improved safety profile

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
M E Pichichero

Abstract

The common adverse reactions associated with diphtheria, tetanus and pertussis (DTP) vaccination are less frequent and less severe with acellular DTP (DTaP) vaccines than with whole cell DTP (DTwP) vaccines. Five key parameters have been identified whose prevalence through the first 48 hours following vaccination accurately characterise the common manifestations of DTaP and DTwP reactogenicity: fever > 37.8 degrees C, moderate or severe fussiness, injection site redness, injection site swelling, and moderate or severe injection site pain. For every DTaP vaccine evaluated, significantly less reactogenicity has been observed in comparison to DTwP vaccines. Although there are differences among the acellular DTaP vaccines in the frequency and severity of some of the adverse reactions, these differences are minor in degree and nature. For both DTaP and DTwP vaccines, local reactions increase in prevalence and severity with successive inoculations. The safety of DTaP vaccines has now been established in infants receiving inoculations at 2,4 and 6 months of age and in other 2 and 3 inoculation sequences below 1 year of age, as well as in toddlers (1 to 3 year olds), preschool children (4 to 6 year olds) and in adults. The increased pu...Continue Reading

Citations

Oct 1, 2015·Journal of Advanced Nursing·Ülkü Yapucu GüneşPetek Bayındır
Nov 29, 2005·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Li-Min HuangChin-Yun Lee
Apr 13, 2000·Pediatric Clinics of North America·M E Pichichero
Feb 28, 2018·Expert Review of Vaccines·Federico Martinón-TorresCarl Heinz Wirsing von König
May 2, 2009·Archives of Pharmacal Research·Kyungdong BaeByungki Hur
Aug 18, 2000·Paediatric Drugs·R T ChenF DeStefano
May 8, 2002·Paediatric Drugs·Dorota Z Girard
Jul 25, 1998·Pediatric Annals·R T Chen, B Hibbs

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