Acephate immunotoxicity in White Leghorn cockerel chicks upon experimental exposure

Environmental Toxicology and Pharmacology
Syamantak M TripathiLaxmi N Sankhala

Abstract

Immunotoxicity for subacute exposure to acephate (O,S-dimethyl-acetylphosphoramidothioate) was assessed in day old White Leghorn (WLH) cockerel chicks. The chicks were divided into five groups. Groups C1 and C2 served as plain control and vehicle control respectively. Chicks of groups T1, T2 and T3 were administered acephate suspended in groundnut oil at 21.3mg/kg, 28.4mg/kg and 42.6mg/kg respectively orally for 28 days. A non-significant reduction in total leukocyte count was observed. Although, anti-Newcastle Disease Virus (NDV) antibody titer, serum total protein (TP), serum globulin, serum albumin and organ:body weight ratios of immune organs were significantly suppressed. The delayed type hypersensitivity response to 2,4-dinitro-1-chlorobenzene (DNCB) was not significantly altered. Histopathologically, bursa and spleen showed mild depletion of lymphocytes. Furthermore, DNA fragmentation assay was performed and detected ladder pattern (180bp) in DNA. It was concluded that subacute acephate exposure at low concentrations may affect immune responses in avian species.

References

Sep 1, 1978·Bulletin of Environmental Contamination and Toxicology·R W WiltroutW S Ceglowski
Mar 31, 2000·Experimental Cell Research·S Nagata
Mar 30, 2001·The Journal of Biological Chemistry·Y ZhangZ Dong
Aug 19, 2007·Biochemical and Biophysical Research Communications·Linfang HuangAkio Koizumi
Sep 30, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S G SukeB D Banerjee
Jan 1, 2006·Toxicology Mechanisms and Methods·M I Girón-PérezM L Robledo-Marenco

❮ Previous
Next ❯

Citations

Apr 1, 2015·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Xiangying LiuXuguo Zhou
Dec 10, 2019·Environmental Toxicology and Pharmacology·Moutushi MandiSumedha Roy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis