Acetabular Labral Reconstruction With Autologous Tendon Tissue in a Porcine Model: In Vivo Histological Assessment and Gene Expression Analysis of the Healing Tissue

The American Journal of Sports Medicine
Yuan-Yuan ShiJian-Quan Wang

Abstract

Acetabular labral reconstruction with autologous tendons is the preferred method for treating a severely damaged labrum. However, the healing process of implants remains unknown. Similar to the human acetabular labrum, the porcine acetabular labrum is a fibrocartilage-like tissue. This study aimed to characterize the histological healing process and gene expression profile of implants in a porcine model of acetabular labral reconstruction. Descriptive laboratory study. Eighteen pigs were included in this study. The pigs underwent unilateral acetabular labral reconstruction. A 1.0 cm-long defect was made at the site of the anterior (cranial) dorsal labrum, which was repaired using an autologous mesogluteus tendon. The pigs were sacrificed at 12 and 24 weeks postoperatively. The implants were subjected to histological assessment and gene expression analysis. The cell phenotype of the implants was visualized using paraffin-embedded sections. Macroscopic observations revealed that at 12 weeks, 8 of 9 implants partially filled the labral defect; by contrast, at 24 weeks, 6 of 9 implants fully filled and 3 implants partially filled the labral defects. Oval- or round-shaped fibrochondrocytes were found in the implants at 12 and 24 wee...Continue Reading

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Citations

Feb 15, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Benjamin G DombItay Perets
Jul 12, 2019·Current Reviews in Musculoskeletal Medicine·Caitlin C Chambers, Alan L Zhang
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Jan 28, 2021·Current Reviews in Musculoskeletal Medicine·Parth LodhiaBenjamin G Domb
Jul 3, 2021·The American Journal of Sports Medicine·Michael P KucharikScott D Martin

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Methods Mentioned

BETA
imaging techniques
PCR

Software Mentioned

SPSS

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

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