Abstract
Acetabular labral reconstruction with autologous tendons is the preferred method for treating a severely damaged labrum. However, the healing process of implants remains unknown. Similar to the human acetabular labrum, the porcine acetabular labrum is a fibrocartilage-like tissue. This study aimed to characterize the histological healing process and gene expression profile of implants in a porcine model of acetabular labral reconstruction. Descriptive laboratory study. Eighteen pigs were included in this study. The pigs underwent unilateral acetabular labral reconstruction. A 1.0 cm-long defect was made at the site of the anterior (cranial) dorsal labrum, which was repaired using an autologous mesogluteus tendon. The pigs were sacrificed at 12 and 24 weeks postoperatively. The implants were subjected to histological assessment and gene expression analysis. The cell phenotype of the implants was visualized using paraffin-embedded sections. Macroscopic observations revealed that at 12 weeks, 8 of 9 implants partially filled the labral defect; by contrast, at 24 weeks, 6 of 9 implants fully filled and 3 implants partially filled the labral defects. Oval- or round-shaped fibrochondrocytes were found in the implants at 12 and 24 wee...Continue Reading
References
Jan 5, 2002·Clinical Orthopaedics and Related Research·J C McCarthyJ Lee
Jun 13, 2003·Archives of Orthopaedic and Trauma Surgery·Wolf PetersenBernhard Tillmann
Apr 20, 2004·Osteoarthritis and Cartilage·H H MiozzariH P Nötzli
Jun 28, 2005·Osteoarthritis and Cartilage·P C M VerdonkG Verbruggen
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Jun 1, 2010·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Marc J PhilipponMichael J Huang
Apr 17, 2012·Osteoarthritis and Cartilage·A A M DhollanderG Verbruggen
Oct 23, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Emmanuel A AudenaertChristophe Pattyn
Mar 2, 2013·The American Journal of Sports Medicine·T Sean LynchBryan T Kelly
May 7, 2013·The American Journal of Sports Medicine·Mark R GeyerKaren K Briggs
Jul 31, 2013·Arthritis and Rheumatism·Nobutake OzekiIchiro Sekiya
Aug 10, 2013·The American Journal of Sports Medicine·Robert E BoykinMarc J Philippon
Nov 5, 2013·The American Journal of Sports Medicine·Benjamin G DombDror Lindner
Nov 26, 2013·Osteoarthritis and Cartilage·C R HenakJ A Weiss
Feb 11, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jeffrey J NeppleCoen A Wijdicks
Feb 13, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Marc J PhilipponCoen A Wijdicks
Jul 6, 2014·Clinical Orthopaedics and Related Research·Maureen K DwyerPhilip C Noble
Nov 2, 2014·The American Journal of Sports Medicine·Simon LeeShane J Nho
Jul 29, 2015·Frontiers in Surgery·Brian J White, Mackenzie M Herzog
Citations
Feb 15, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Benjamin G DombItay Perets
Feb 21, 2019·The American Journal of Sports Medicine·Zheng-Zheng ZhangBin Song
Jul 12, 2019·Current Reviews in Musculoskeletal Medicine·Caitlin C Chambers, Alan L Zhang
Sep 13, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Marc J PhilipponKaren K Briggs
Jan 17, 2019·Journal of Hip Preservation Surgery·Ran AtzmonEhud Rath
Dec 4, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ravikumar RajappaScott D Martin
Aug 3, 2017·Scientific Reports·Chenxi LiYingfang Ao
Jan 28, 2021·Current Reviews in Musculoskeletal Medicine·Parth LodhiaBenjamin G Domb
Nov 17, 2020·Frontiers in Surgery·Felipe S BessaJorge Chahla
Jul 3, 2021·The American Journal of Sports Medicine·Michael P KucharikScott D Martin
Aug 6, 2021·Orthopaedic Surgery·Feng-Yuan ZhaoJian-Quan Wang