PMID: 8464325Jan 1, 1993Paper

Acetaldehyde-collagen adducts in N-nitrosodimethylamine-induced liver cirrhosis in rats

Life Sciences
E BaraonaC S Lieber

Abstract

Increased acetaldehyde levels have been found in non-alcoholic liver diseases and an acetaldehyde-collagen adduct has been reported in rats with CCl4-induced cirrhosis. In cytosol and microsomes of rats with cirrhosis produced by N-nitrosodimethylamine, a similar acetaldehyde-protein adduct of approximately 200 kD was recognized by rabbit IgG raised against either an in vitro produced hemocyanin-acetaldehyde adduct or an in vivo occurring P4502E1-acetaldehyde adduct isolated from alcohol-fed rats, as well as by anti-rat collagen (I) IgG. Its immune complexes contained 3 proteins that reacted with the anti-collagen IgG and were digested by collagenase: 2 proteins with molecular weights similar to procollagens alpha 1 and alpha 2, and a beta 1,2(I)-like protein which was readily produced by in vitro modification of cytosol with acetaldehyde.

References

Nov 30, 1990·Biochemical and Biophysical Research Communications·U J BehrensC S Lieber
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O NiemeläY Israel
Dec 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·X L MaC S Lieber
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Citations

Apr 21, 1998·European Journal of Pharmacology·H MasunagaK Higashio
Dec 1, 1995·Mutation Research·N P SinghA Khan
Dec 18, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·D C TavaresC S Takahashi
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Svegliati-BaroniC S Lieber
Apr 12, 2000·Journal of Gastroenterology and Hepatology·I Shimizu

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