Acetate attenuates perioperative neurocognitive disorders in aged mice

Aging
Cen WenYanping Zha

Abstract

Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotomy model with isoflurane anesthesia to study the effects of acetate on perioperative neurocognitive disorders in aged mice. Neurocognitive function was assessed with open-field tests and Morris water maze tests 3 or 7 days post-surgery. Acetate ameliorated the surgery-induced cognitive deficits of aged mice and inhibited the activation of IBA-1, a marker of microglial activity. Acetate also reduced expression of inflammatory proteins (tumor necrosis factor-α, interleukin-1β and interleukin-6), oxidative stress factors (NADPH oxidase 2, inducible nitric oxide synthase and reactive oxygen species), and signaling molecules (nuclear factor kappa B and mitogen-activated protein kinase) in the hippocampus. BV2 microglial cells were used to verify the anti-inflammatory effects of acetate in vitro. Acetate suppressed inflammation in lipopolysaccharide-treated BV2 microglial cells, but not when GPR43 was silenced. These resu...Continue Reading

References

Sep 22, 2006·Antioxidants & Redox Signaling·David W InfangerRobin L Davisson
Aug 7, 2007·International Review of Neurobiology·Ashley ReynoldsHoward E Gendelman
Jun 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·José A MattaGerard P Ahern
Feb 10, 2009·Current Alzheimer Research·Huafeng Wei, Zhongcong Xie
Mar 25, 2009·Antioxidants & Redox Signaling·Silvia Sorce, Karl-Heinz Krause
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Niccolò TerrandoMervyn Maze
Dec 23, 2011·Annals of Neurology·Niccolò TerrandoMervyn Maze
Dec 24, 2011·Behavioural Brain Research·Daowei LinZhiyi Zuo
Aug 14, 2012·Brain, Behavior, and Immunity·Colm Cunningham, Alasdair M J Maclullich
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ruth M BarrientosSteven F Maier
Nov 23, 2013·Annals of Surgery·Marcela P VizcaychipiDaqing Ma
Jan 7, 2014·Advances in Immunology·Jian TanLaurence Macia
Oct 13, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wei WangFuzhou Wang
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saskia M BurmJeffrey J Bajramovic
Jun 25, 2015·Frontiers in Aging Neuroscience·Ganna AndrosovaReinhard Schneider
Jan 29, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeongho ParkChang H Kim
Feb 13, 2016·Frontiers in Immunology·Zhiwei Ang, Jeak Ling Ding
May 20, 2016·Clinical & Translational Immunology·Renan Corrêa-OliveiraMarco Aurélio R Vinolo
Oct 19, 2016·The Journal of Pharmacology and Experimental Therapeutics·Samina Salim
Aug 30, 2017·Frontiers in Cellular Neuroscience·María Del Mar Fernández-ArjonaMaría D López-Ávalos
Sep 5, 2017·Biological & Pharmaceutical Bulletin·Jiaming LiuFangyan Wang
Nov 29, 2017·Neuroscience and Biobehavioral Reviews·David R SkvarcLaura Gray
May 20, 2018·Journal of Neuroinflammation·Chunxia HuangRaymond Chuen Chung Chang
Jul 25, 2018·Brain, Behavior, and Immunity·Martins Back NettoFabricia Petronilho
Oct 17, 2018·Anesthesia and Analgesia·L EveredUNKNOWN Nomenclature Consensus Working Group
Oct 24, 2018·EBioMedicine·Azeem AlamDaqing Ma
Dec 7, 2018·Clinical Interventions in Aging·Nalini KotekarRavishankar Nagaraj

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Citations

Sep 10, 2020·Frontiers in Cellular Neuroscience·Youmei ZuoJing Wu
Sep 26, 2020·Frontiers in Cellular Neuroscience·Wenguo FanHongwen He
May 5, 2021·CNS Neuroscience & Therapeutics·Zhiwen ShenJunhua Li

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay
electrophoresis
transfection

Software Mentioned

Supermaze + V
Supermaze
ImageJ
+ V
GraphPad Prism

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